The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes
about
Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicityOmi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's diseaseCharacterizing HSF1 Binding and Post-Translational Modifications of hsp70 Promoter in Cultured Cortical Neurons: Implications in the Heat-Shock ResponseValproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylationHeat shock factor 1 regulates lifespan as distinct from disease onset in prion disease.Mutant huntingtin impairs Ku70-mediated DNA repair.Proteostasis in striatal cells and selective neurodegeneration in Huntington's disease.Hsp70 and its molecular role in nervous system diseasesImpaired heat shock response in cells expressing full-length polyglutamine-expanded huntingtin.The biology of proteostasis in aging and disease.Transcription, epigenetics and ameliorative strategies in Huntington's Disease: a genome-wide perspectiveMolecular interaction between the chaperone Hsc70 and the N-terminal flank of huntingtin exon 1 modulates aggregationChaperonopathies and chaperonotherapy.Polyglutamine neurodegeneration: protein misfolding revisited.In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis.Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease.Multiple roles of HDAC inhibition in neurodegenerative conditions.The role of molecular chaperones in human misfolding diseases.Protein aggregates in Huntington's disease.Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.Current understanding on the pathogenesis of polyglutamine diseases.Ultra-Early Phase pathologies of Alzheimer's disease and other neurodegenerative diseases.Modulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders.A link between chromatin condensation mechanisms and Huntington's disease: connecting the dots.Deficit of heat shock transcription factor 1-heat shock 70 kDa protein 1A axis determines the cell death vulnerability in a model of spinocerebellar ataxia type 6.Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor.Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila.Mutant huntingtin fragment selectively suppresses Brn-2 POU domain transcription factor to mediate hypothalamic cell dysfunctionProteostasis of Huntingtin in Health and DiseaseThe heat shock response in neurons and astroglia and its role in neurodegenerative diseases.Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity.Heat shock proteins in neurodegenerative diseases: pathogenic roles and therapeutic implications.The role of HSPA12B in regulating neuronal apoptosis.Protective up-regulation of CK2 by mutant huntingtin in cells co-expressing NMDA receptors.Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration.RTP801 Is Involved in Mutant Huntingtin-Induced Cell Death.Mitochondrial Quality Control in Neurodegenerative Diseases: Focus on Parkinson's Disease and Huntington's Disease.
P2860
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P2860
The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes
description
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im Januar 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/01/24)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/01/24)
@nl
наукова стаття, опублікована в січні 2007
@uk
مقالة علمية (نشرت في 24-1-2007)
@ar
name
The induction levels of heat s ...... ingtin among neuronal subtypes
@ast
The induction levels of heat s ...... ingtin among neuronal subtypes
@en
The induction levels of heat s ...... ingtin among neuronal subtypes
@nl
type
label
The induction levels of heat s ...... ingtin among neuronal subtypes
@ast
The induction levels of heat s ...... ingtin among neuronal subtypes
@en
The induction levels of heat s ...... ingtin among neuronal subtypes
@nl
prefLabel
The induction levels of heat s ...... ingtin among neuronal subtypes
@ast
The induction levels of heat s ...... ingtin among neuronal subtypes
@en
The induction levels of heat s ...... ingtin among neuronal subtypes
@nl
P2093
P1476
The induction levels of heat s ...... ingtin among neuronal subtypes
@en
P2093
Hitoshi Okazawa
Ichiro Kanazawa
Kazuhiko Tagawa
Mei-Ling Qi
Miho Murata
Reina Inagaki
Shigeki Marubuchi
Takuya Tamura
P304
P356
10.1523/JNEUROSCI.4522-06.2007
P407
P577
2007-01-24T00:00:00Z