Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1
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The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complexTSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomesCbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motilityStabilization and activation of p53 by the coactivator protein TAFII31Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7An RBCC protein implicated in maintenance of steady-state neuregulin receptor levelsMammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugatesTEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulumCbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiationHECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACKThreshold-controlled ubiquitination of the EGFR directs receptor fateStructural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteinsTal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus buddingAbi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosisStabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8A novel role of Sprouty 2 in regulating cellular apoptosisCIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinasesProtein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexinTyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its functionThe IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptorRNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localizationIdentification and functional characterization of an Src homology domain 3 domain-binding site on CblStructural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substratesSuppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signalingAn unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosisActivated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradationClathrin-dependent endocytosisSprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling.The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-KitCbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytesFunctional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling.Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3SU6656, a selective src family kinase inhibitor, used to probe growth factor signalingLRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradationStructural basis for autoinhibition and phosphorylation-dependent activation of c-CblBiological influence of Hakai in cancer: a 10-year reviewRegulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
P2860
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P2860
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Ubiquitin ligase activity and ...... actor signaling by c-Cbl/Sli-1
@ast
Ubiquitin ligase activity and ...... actor signaling by c-Cbl/Sli-1
@en
type
label
Ubiquitin ligase activity and ...... actor signaling by c-Cbl/Sli-1
@ast
Ubiquitin ligase activity and ...... actor signaling by c-Cbl/Sli-1
@en
prefLabel
Ubiquitin ligase activity and ...... actor signaling by c-Cbl/Sli-1
@ast
Ubiquitin ligase activity and ...... actor signaling by c-Cbl/Sli-1
@en
P2093
P3181
P1433
P1476
Ubiquitin ligase activity and ...... actor signaling by c-Cbl/Sli-1
@en
P2093
Ettenberg SA
Levkowitz G
Lipkowitz S
Tsygankov AY
Waterman H
P304
P3181
P356
10.1016/S1097-2765(00)80231-2
P407
P577
1999-12-01T00:00:00Z