p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin.
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Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinaseTopographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domainReduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetesExpression of the splice variants of the p85alpha regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patientsPositive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signalingp85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiationTransduction pathways regulating the trophic effects of Saccharomyces boulardii in rat intestinal mucosaInsulin signal transduction in rat small intestine: role of MAP kinases in expression of mucosal hydrolasesPhosphoinositide 3-kinase p85beta regulates invadopodium formation.Intermolecular interactions of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase.Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase.Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations.Targeting the phosphoinositide 3-kinase pathway in hematologic malignanciesProtein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistanceCharacterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alphaPTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle.New responsibilities for the PI3K regulatory subunit p85 alpha.Phosphoinositide 3-kinase inhibition in cancer treatment.p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity.Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin populationIntracellular localization of phosphatidylinositide 3-kinase and insulin receptor substrate-1 in adipocytes: potential involvement of a membrane skeleton.Low conservation and species-specific evolution of alternative splicing in humans and mice: comparative genomics analysis using well-annotated full-length cDNAs.Piceatannol suppresses the metastatic potential of MCF10A human breast epithelial cells harboring mutated H-ras by inhibiting MMP-2 expression.Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications.Inhibitors of phosphatidylinositol-3-kinase in cancer therapyTargeting the PI3K pathway for cancer therapy.Therapeutic targeting of EGFR-activated metabolic pathways in glioblastoma.Cell activation-induced phosphoinositide 3-kinase alpha/beta dimerization regulates PTEN activity.Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit.PI 3-kinase regulatory subunits as regulators of the unfolded protein response.Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition.Acidification and glucocorticoids independently regulate branched-chain alpha-ketoacid dehydrogenase subunit genes.Binding of a diphosphotyrosine-containing peptide that mimics activated platelet-derived growth factor receptor beta induces oligomerization of phosphatidylinositol 3-kinase.Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinaseEffect of nutritional state on the formation of a complex involving insulin receptor IRS-1, the 52 kDa Src homology/collagen protein (Shc) isoform and phosphatidylinositol 3'-kinase activityMolecular mechanisms of contraction-regulated cardiac glucose transport.
P2860
Q24531326-5BD8A97B-DB14-4834-8B04-06DAF4859220Q24797020-698F0D51-5595-4D16-AE79-C6615881B8DEQ28249965-248F95E4-2A42-4A6E-B51A-58CC96D37AA6Q28344700-B78332C1-0D63-4977-B05F-E60560614578Q28363309-21CF90FA-975C-4CD2-9888-5FE1B3F0C43BQ28506865-19A2D9D9-4168-4DCC-9610-CDE2753C94BAQ28513416-9DC435B9-F96B-426F-9C0F-DD31E7F9E312Q28573133-C8AB48F1-6529-4119-B5C9-7F961623A001Q28576668-53878103-17CB-43B0-8DA0-1E584F5E0E99Q29347240-757F2A7E-46EE-498A-B9F3-1D2A3C8A6D12Q30175781-1CAC3ACE-CF67-4287-B02C-FBB0F06A7032Q31712047-F97F085B-1B6C-41CB-B97D-047BA2DC4F66Q31924344-12491FEB-DA60-4796-BAF3-0680C306D4A8Q33558141-1E7428BB-CD00-4755-8741-2CEA872831B2Q33588931-B771FD0D-D68B-4875-9699-DF2F6E48C0D3Q34012425-A2B0A0F9-2DD3-4BA8-A670-C167D3048499Q34038299-EF7B5299-838E-4EC7-A030-836ECDAE743FQ34272789-C53FCD7E-45D2-488C-9095-8B5C1F956750Q34433101-41DC8909-22BA-4634-BAC9-F8308DE58236Q34467814-DA261E3C-3156-458C-B059-97150ACCE475Q34481485-D6293396-A86B-4E58-B3E1-AC0C07D15205Q34550411-D321999E-3B96-4394-AF88-0FED34137DF0Q35112931-C46070CC-AE87-43FF-BAAE-837FE4F4B717Q36255197-9811E7C8-03EF-4A03-9AC6-483C89214980Q36972162-52D2DEA4-FC0A-4CD5-B90C-0FF98C836F13Q37265640-96D35CCB-1875-400C-90DC-2BCE1EB2D5CCQ37376749-35FB8C3A-A37B-433A-9405-F590F9A006C6Q37454384-F09B1E24-CD4A-4ED8-9ED7-3F7DAB881B5DQ37696628-CEB340A8-0FFB-4C1C-AB56-03715E8BEB9DQ38019609-35FBC4E9-607A-41AC-93E3-4DEC9DAAE2CBQ38111449-697067DA-C8A8-4BF3-A83F-02E941197F8AQ38981868-2A2E2B2A-C1AA-414E-8819-5D4CB63A1312Q39456427-5033A861-BB30-4F34-8884-F457841D604FQ39602961-C838AC76-B6D2-4DF2-8A4C-40F5BD342F7DQ40442177-5C99F7AA-DA18-4F13-8A7A-3E246C172BE7Q40814979-51C3BF8D-7D82-4999-A0DE-E33B50CC0B8EQ40990897-9D6E8896-0748-4E7E-813F-041C8045472BQ41060477-B2766D14-C68A-451B-A598-CDF3A95B676EQ42030375-4748A5B1-C393-4D48-8F96-A0C0275B5853Q42044135-5DEF9B52-1CB4-449D-A77B-5370D44074E8
P2860
p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin.
description
1997 nî lūn-bûn
@nan
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
p85alpha gene generates three ...... levating responses to insulin.
@ast
p85alpha gene generates three ...... levating responses to insulin.
@en
type
label
p85alpha gene generates three ...... levating responses to insulin.
@ast
p85alpha gene generates three ...... levating responses to insulin.
@en
prefLabel
p85alpha gene generates three ...... levating responses to insulin.
@ast
p85alpha gene generates three ...... levating responses to insulin.
@en
P2093
P2860
P356
P1476
p85alpha gene generates three ...... levating responses to insulin.
@en
P2093
Fukushima Y
Katagiri H
P2860
P304
P356
10.1074/JBC.272.12.7873
P407
P577
1997-03-01T00:00:00Z