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Linkage of osteoporosis to chromosome 20p12 and association to BMP2A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hipGenome-wide association yields new sequence variants at seven loci that associate with measures of obesityNew sequence variants associated with bone mineral densityAssessment of gene-by-sex interaction effect on bone mineral densityLarge scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populationsEuropean bone mineral density loci are also associated with BMD in East-Asian populationsSequence variants in the CLDN14 gene associate with kidney stones and bone mineral densityMeta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22A variant in MCF2L is associated with osteoarthritis.Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetesGenetics of gene expression and its effect on diseaseWhole-genome sequencing identifies EN1 as a determinant of bone density and fracture.A common biological basis of obesity and nicotine addictionGenome-wide meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR) geneAncestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus.Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies.Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture riskGenome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locusMeta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study.Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche.Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profileVariants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry.Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome.Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis.Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studiesSequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures.Two-step activation of meiosis by the mat1 locus in Schizosaccharomyces pombe.The rate of meiotic gene conversion varies by sex and age.Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation.Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.Two Rare Mutations in the COL1A2 Gene Associate With Low Bone Mineral Density and Fractures in Iceland.The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males.Multiple genetic loci for bone mineral density and fractures.Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits.Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis.Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus.
P50
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P50
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