The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction.
about
Efficient trans-cleavage of a stem-loop RNA substrate by a ribozyme derived from neurospora VS RNADefining the chemical groups essential for Tetrahymena group I intron function by nucleotide analog interference mappingRas-catalyzed hydrolysis of GTP: a new perspective from model studiesFunctional identification of catalytic metal ion binding sites within RNA.Structural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozymeThe structure of the box C/D enzyme reveals regulation of RNA methylationCrystal structure of a phage Twort group I ribozyme-product complexThree metal ions at the active site of the Tetrahymena group I ribozymeThermodynamics of 2'-ribose substitutions in UUCG tetraloopsRecent advances in the elucidation of the mechanisms of action of ribozymesMinor groove recognition of the conserved G.U pair at the Tetrahymena ribozyme reaction site.In vitro adaptation of a ligase ribozyme for activity under a low-pH condition.An unconventional origin of metal-ion rescue and inhibition in the Tetrahymena group I ribozyme reaction.A kinetic and thermodynamic framework for the Azoarcus group I ribozyme reaction.Dissection of a metal-ion-mediated conformational change in Tetrahymena ribozyme catalysisUse of binding energy by an RNA enzyme for catalysis by positioning and substrate destabilization.Nonspecific binding to structured RNA and preferential unwinding of an exposed helix by the CYT-19 protein, a DEAD-box RNA chaperone.Thermodynamic and structural characterization of 2'-nitrogen-modified RNA duplexes.An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site.Exploring purine N7 interactions via atomic mutagenesis: the group I ribozyme as a case study.The change in hydrogen bond strength accompanying charge rearrangement: implications for enzymatic catalysis.Bacterial toxin RelE: a highly efficient ribonuclease with exquisite substrate specificity using atypical catalytic residuesTransgalactosylation by thermostable beta-glycosidases from Pyrococcus furiosus and Sulfolobus solfataricus. Binding interactions of nucleophiles with the galactosylated enzyme intermediate make major contributions to the formation of new beta-glycoSpecificity from steric restrictions in the guanosine binding pocket of a group I ribozyme.The two steps of group II intron self-splicing are mechanistically distinguishable.Plasticity of archaeal C/D box sRNA biogenesis.Metal ion interaction with cosubstrate in self-splicing of group I introns.RISC is a 5' phosphomonoester-producing RNA endonuclease.Probing the role of a secondary structure element at the 5'- and 3'-splice sites in group I intron self-splicing: the tetrahymena L-16 ScaI ribozyme reveals a new role of the G.U pair in self-splicingPeptide release on the ribosome depends critically on the 2' OH of the peptidyl-tRNA substrate.A Role for the 2' OH of peptidyl-tRNA substrate in peptide release on the ribosome revealed through RF-mediated rescue.Crystal structure of a group I intron splicing intermediate.The chemical basis of adenosine conservation throughout the Tetrahymena ribozyme.2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups.Phosphorane intermediate vs. leaving group stabilization by intramolecular hydrogen bonding in the cleavage of trinucleoside monophosphates: implications for understanding catalysis by the large ribozymes.Catalysis by RNase P RNA: unique features and unprecedented active site plasticity.Substrate-assisted catalysis of peptide bond formation by the ribosome.Kinetic characterization of the first step of the ribozyme-catalyzed trans excision-splicing reaction.Phosphodiester models for cleavage of nucleic acids.Understanding catalysis of phosphate-transfer reactions by the large ribozymes.
P2860
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P2860
The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction.
description
1993 nî lūn-bûn
@nan
1993 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction.
@ast
The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction.
@en
type
label
The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction.
@ast
The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction.
@en
prefLabel
The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction.
@ast
The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction.
@en
P2093
P356
P1433
P1476
The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction.
@en
P2093
P304
P356
10.1021/BI00083A035
P407
P577
1993-08-01T00:00:00Z