EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia.
about
How do cilia organize signalling cascades?Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.Novel clades of the HU/IHF superfamily point to unexpected roles in the eukaryotic centrosome, chromosome partitioning, and biologic conflicts.Smoothened Regulation: A Tale of Two Signals.Proteomics of Primary Cilia by Proximity LabelingSpecific variants in WDR35 cause a distinctive form of Ellis-van Creveld syndrome by disrupting the recruitment of the EvC complex and SMO into the cilium.Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice.Bacterial calpains and the evolution of the calpain (C2) family of peptidasesSmoothened regulation in response to Hedgehog stimulation.Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary ciliumCholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.An essential role for Grk2 in Hedgehog signalling downstream of Smoothened.G-protein-coupled receptors, Hedgehog signaling and primary cilia.Sonic hedgehog signaling in Basal cell nevus syndrome.Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy.Novel mutations in EVC cause aberrant splicing in Ellis-van Creveld syndrome.EVC gene polymorphisms and risks of isolated hypospadias - a preliminary study.Disruption of sonic hedgehog signaling in Ellis-van Creveld dwarfism confers protection against bipolar affective disorder.Activation of SMOEvolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.Ellis-van Creveld syndrome and profound deafness resulted by sequence variants in the EVC/EVC2 and TMC1 genes.SMO translocates to the ciliumEFCAB7:IQCE binds EVC2:EVCEVC2:EVC binds p-SMOGLI:SUFU translocates to the ciliary tip in response to Hh signalingG-protein-coupled receptors and localized signaling in the primary cilium during ventral neural tube patterning.Truncation and microdeletion of EVC/EVC2 with missense mutation of EFCAB7 in Ellis-van Creveld syndrome.Exome sequencing revealed a splice site variant in the IQCE gene underlying post-axial polydactyly type A restricted to lower limb.Platinum Nanoparticles Decrease Reactive Oxygen Species and Modulate Gene Expression without Alteration of Immune Responses in THP-1 Monocytes.Clinical Genetics of Polydactyly: An Updated Review
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P2860
EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia.
description
2014 nî lūn-bûn
@nan
2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
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2014年论文
@wuu
name
EFCAB7 and IQCE regulate hedge ...... to the base of primary cilia.
@ast
EFCAB7 and IQCE regulate hedge ...... to the base of primary cilia.
@en
type
label
EFCAB7 and IQCE regulate hedge ...... to the base of primary cilia.
@ast
EFCAB7 and IQCE regulate hedge ...... to the base of primary cilia.
@en
prefLabel
EFCAB7 and IQCE regulate hedge ...... to the base of primary cilia.
@ast
EFCAB7 and IQCE regulate hedge ...... to the base of primary cilia.
@en
P2093
P2860
P50
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P1476
EFCAB7 and IQCE regulate hedge ...... to the base of primary cilia.
@en
P2093
Casey E Hughes
Karolin V Dorn
Priscilla Sugianto
Rajat Rohatgi
P2860
P304
P356
10.1016/J.DEVCEL.2014.01.021
P407
P577
2014-02-27T00:00:00Z