PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. - Wikidata - wikimedia - TriplyDB

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.

http://www.wikidata.org/entity/Q33627219

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DNA Damage: A Main Determinant of Vascular Aging Upregulation of SOX4 antagonizes cellular senescence in esophageal squamous cell carcinoma Clinical strategies and animal models for developing senolytic agents.Functional role of cellular senescence in biliary injury Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity.Ex Vivo Expansion and In Vivo Self-Renewal of Human Muscle Stem Cells.RMEL3, a novel BRAFV600E-associated long noncoding RNA, is required for MAPK and PI3K signaling in melanoma.Physiological and pathological consequences of cellular senescence.Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase.Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses.Hydrogen-Rich Saline Alleviates Kidney Fibrosis Following AKI and Retains Klotho Expression Klotho, an antiaging molecule, attenuates oxidant-induced alveolar epithelial cell mtDNA damage and apoptosis.Translating the Science of Aging into Therapeutic Interventions.Molecular and physiological manifestations and measurement of aging in humans.Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence.Senescent cells: an emerging target for diseases of ageing.A novel plasminogen activator inhibitor-1 inhibitor, TM5441, protects against high-fat diet-induced obesity and adipocyte injury in mice.Generation of human iPSCs from urine derived cells of patient with a novel heterozygous PAI-1 mutation.Plasminogen activator inhibitor-1 is associated with leukocyte telomere length in American Indians: findings from the Strong Heart Family Study.Generation of human iPSCs from urine derived cells of a patient with a novel homozygous PAI-1 mutation.Inorganic Phosphate Activates the AKT/mTORC1 Pathway and Shortens the Life Span of an α‑Klotho-Deficient Model.PAI-1 is a critical regulator of FGF23 homeostasis Alpha-1 Antitrypsin Investigations Using Animal Models of Emphysema Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease.A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence.αKlotho Mitigates Progression of AKI to CKD through Activation of Autophagy Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease.Pharmacological Targeting of Plasminogen Activator Inhibitor-1 Decreases Vascular Smooth Muscle Cell Migration and Neointima Formation.TM5441, a plasminogen activator inhibitor-1 inhibitor, protects against high fat diet-induced non-alcoholic fatty liver disease.A null mutation in SERPINE1 protects against biological aging in humans.The serine protease inhibitor serpinB2 binds and stabilizes p21 in senescent cells.Plasmin Prevents Dystrophic Calcification After Muscle Injury.Adipose Tissue-Derived Plasminogen Activator Inhibitor-1 Function and Regulation.Stress granules counteract senescence by sequestration of PAI-1.Overexpression of Klotho Inhibits HELF Fibroblasts SASP-related Protumoral Effects on Non-small Cell Lung Cancer Cells.FGF23 Actions on Target Tissues-With and Without Klotho.Serpine1 Knockdown Enhances MMP Activity after Flexor Tendon Injury in Mice: Implications for Adhesions Therapy.Aerobic exercise-stimulated Klotho upregulation extends life span by attenuating the excess production of reactive oxygen species in the brain and kidney

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P2860

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.

http://www.wikidata.org/entity/Q33627219

description

2014 nî lūn-bûn

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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի ապրիլին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.

@ast

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.

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type

label

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.

@ast

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.

@en

prefLabel

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.

@ast

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.

@en

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PNAS.1321942111

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Proceedings of the National Academy of Sciences of the United States of America

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PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice

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Aaron T Place

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Amanda E Boe

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Daniela Urich

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Douglas E Vaughan

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G R Scott Budinger

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Gökhan M Mutlu

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Luisa Morales-Nebreda

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Mesut Eren

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Sheila B Murphy

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Susan E Quaggin

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P2860

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Telomere measurement by quantitative PCR

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis

Suppression of aging in mice by the hormone Klotho

Furin at the cutting edge: from protein traffic to embryogenesis and disease

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Augmented Wnt signaling in a mammalian model of accelerated aging

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