Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice. - Wikidata - wikimedia - TriplyDB

Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice.

Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice.

http://www.wikidata.org/entity/Q33658791

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The ancient and evolving roles of cohesin in gene expression and DNA repair Replication stress in Mammalian cells and its consequences for mitosis The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance.Prognostic Biomarker Identification Through Integrating the Gene Signatures of Hepatocellular Carcinoma Properties RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity.DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions.Cohesin is required for activation of MYC by estradiol.Altered cohesin gene dosage affects Mammalian meiotic chromosome structure and behavior.Mutations in RAD21 disrupt regulation of APOB in patients with chronic intestinal pseudo-obstruction The AtRAD21.1 and AtRAD21.3 Arabidopsis cohesins play a synergistic role in somatic DNA double strand break damage repair.IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations.The regulatory and predictive functions of miR-17 and miR-92 families on cisplatin resistance of non-small cell lung cancer Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres.H2AX phosphorylation at the sites of DNA double-strand breaks in cultivated mammalian cells and tissues.RAD21 mutations cause a human cohesinopathy Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms Deregulation of RAD21 and RUNX1 expression in endometrial cancer.Higher-order orchestration of hematopoiesis: is cohesin a new player?Aneuploidy in health, disease, and aging.Intestinal-specific activatable Myb initiates colon tumorigenesis in mice.Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury.RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas.Haploinsufficiency in mouse models of DNA repair deficiency: modifiers of penetrance.Colorectal cancer mouse models: integrating inflammation and the stroma.Diverse developmental disorders from the one ring: distinct molecular pathways underlie the cohesinopathies.Cohesin in cancer: chromosome segregation and beyond.Cohesin mutations in human cancer The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9.Downregulation of Cohesin Loading Factor Nipped-B-Like Protein (NIPBL) Induces Cell Cycle Arrest, Apoptosis, and Autophagy of Breast Cancer Cell Lines.Genetic basis of cohesinopathies.The DNA methylome of DDR genes and benefit from RT or TMZ in IDH mutant low-grade glioma treated in EORTC 22033.Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver.Expression of RAD21 immunoreactivity in myenteric neurons of the human and mouse small intestine AIMP3 Deletion Induces Acute Radiation Syndrome-like Phenotype in Mice

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P2860

Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice.

http://www.wikidata.org/entity/Q33658791

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Rad21-cohesin haploinsufficien ...... inal radiosensitivity in mice.

@ast

Rad21-cohesin haploinsufficien ...... inal radiosensitivity in mice.

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type

label

Rad21-cohesin haploinsufficien ...... inal radiosensitivity in mice.

@ast

Rad21-cohesin haploinsufficien ...... inal radiosensitivity in mice.

@en

prefLabel

Rad21-cohesin haploinsufficien ...... inal radiosensitivity in mice.

@ast

Rad21-cohesin haploinsufficien ...... inal radiosensitivity in mice.

@en

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JOURNAL.PONE.0012112

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Rad21-cohesin haploinsufficien ...... inal radiosensitivity in mice.

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Esther Appeldoorn

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Huiling Xu

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Ivan Bertoncello

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Jeroen Essers

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Jonathan M Tomaszewski

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Jordane Malaterre

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Kuhendra Balakrishnan

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Martin F Lavin

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Matthew Beasley

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Melisa Vazquez

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P2860

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks

Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse

Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae

A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

The incidence and gene frequency of ataxia-telangiectasia in the United States

Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome

Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae.

Cohesins: chromosomal proteins that prevent premature separation of sister chromatids

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e12112

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scholarly article

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10.1371/JOURNAL.PONE.0012112

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8

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Robert G. Ramsay

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2010-08-12T00:00:00Z

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45651334

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20711430

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haploinsufficiency

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2920816

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