Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice.
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The ancient and evolving roles of cohesin in gene expression and DNA repairReplication stress in Mammalian cells and its consequences for mitosisThe cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertilityCohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modulesSeparase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in miceLoss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance.Prognostic Biomarker Identification Through Integrating the Gene Signatures of Hepatocellular Carcinoma PropertiesRAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity.DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions.Cohesin is required for activation of MYC by estradiol.Altered cohesin gene dosage affects Mammalian meiotic chromosome structure and behavior.Mutations in RAD21 disrupt regulation of APOB in patients with chronic intestinal pseudo-obstructionThe AtRAD21.1 and AtRAD21.3 Arabidopsis cohesins play a synergistic role in somatic DNA double strand break damage repair.IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations.The regulatory and predictive functions of miR-17 and miR-92 families on cisplatin resistance of non-small cell lung cancerCohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres.H2AX phosphorylation at the sites of DNA double-strand breaks in cultivated mammalian cells and tissues.RAD21 mutations cause a human cohesinopathyCohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasmsDeregulation of RAD21 and RUNX1 expression in endometrial cancer.Higher-order orchestration of hematopoiesis: is cohesin a new player?Aneuploidy in health, disease, and aging.Intestinal-specific activatable Myb initiates colon tumorigenesis in mice.Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury.RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas.Haploinsufficiency in mouse models of DNA repair deficiency: modifiers of penetrance.Colorectal cancer mouse models: integrating inflammation and the stroma.Diverse developmental disorders from the one ring: distinct molecular pathways underlie the cohesinopathies.Cohesin in cancer: chromosome segregation and beyond.Cohesin mutations in human cancerThe cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9.Downregulation of Cohesin Loading Factor Nipped-B-Like Protein (NIPBL) Induces Cell Cycle Arrest, Apoptosis, and Autophagy of Breast Cancer Cell Lines.Genetic basis of cohesinopathies.The DNA methylome of DDR genes and benefit from RT or TMZ in IDH mutant low-grade glioma treated in EORTC 22033.Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver.Expression of RAD21 immunoreactivity in myenteric neurons of the human and mouse small intestineAIMP3 Deletion Induces Acute Radiation Syndrome-like Phenotype in Mice
P2860
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P2860
Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Rad21-cohesin haploinsufficien ...... inal radiosensitivity in mice.
@ast
Rad21-cohesin haploinsufficien ...... inal radiosensitivity in mice.
@en
type
label
Rad21-cohesin haploinsufficien ...... inal radiosensitivity in mice.
@ast
Rad21-cohesin haploinsufficien ...... inal radiosensitivity in mice.
@en
prefLabel
Rad21-cohesin haploinsufficien ...... inal radiosensitivity in mice.
@ast
Rad21-cohesin haploinsufficien ...... inal radiosensitivity in mice.
@en
P2093
P2860
P1433
P1476
Rad21-cohesin haploinsufficien ...... inal radiosensitivity in mice.
@en
P2093
Esther Appeldoorn
Huiling Xu
Ivan Bertoncello
Jeroen Essers
Jonathan M Tomaszewski
Jordane Malaterre
Kuhendra Balakrishnan
Martin F Lavin
Matthew Beasley
Melisa Vazquez
P2860
P304
P356
10.1371/JOURNAL.PONE.0012112
P407
P577
2010-08-12T00:00:00Z