Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform
about
Leu138 in bovine prion peptide fibrils is involved in seeding discrimination related to codon 129 M/V polymorphism in the prion peptide seeding experimentAmyloid aggregates of the HET-s prion protein are infectious.Unique Structural Characteristics of the Rabbit Prion ProteinSolution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoformPrPC directly interacts with proteins involved in signaling pathwaysEffects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's diseaseEffects of beta-sheet breaker peptide polymers on scrapie-infected mouse neuroblastoma cells and their affinities to prion protein fragment PrP(81-145).Rapid acquisition of beta-sheet structure in the prion protein prior to multimer formation.Mapping the prion protein using recombinant antibodies.Cellular biology of prion diseases.Heparin binding confers prion stability and impairs its aggregation.A protease-resistant 61-residue prion peptide causes neurodegeneration in transgenic mice.One O-linked sugar can affect the coil-to-beta structural transition of the prion peptideDisruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity.Propagation of prion strains through specific conformers of the prion proteinSubcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains.Recombinant scrapie-like prion protein of 106 amino acids is soluble.Antibody-based immunotherapeutic attempts in experimental animal models of prion diseases.Prion protein self-interaction in prion disease therapy approaches.A monomer-dimer equilibrium of a cellular prion protein (PrPC) not observed with recombinant PrP.Neurodegenerative Disease Transmission and Transgenesis in Mice.Mad cow disease and Creutzfeldt-Jakob disease--is there a link?Prion protein and scrapie susceptibility.Competing intrachain interactions regulate the formation of beta-sheet fibrils in bovine PrP peptides.Species barrier in prion diseases: a kinetic interpretation based on the conformational adaptation of the prion protein.Polymorphisms at amino acid residues 141 and 154 influence conformational variation in ovine PrP.Specific binding of normal prion protein to the scrapie form via a localized domain initiates its conversion to the protease-resistant state.PrPSc-like prion protein peptide inhibits the function of cellular prion protein.Cryptic epitopes in N-terminally truncated prion protein are exposed in the full-length molecule: dependence of conformation on pH.Conformational change, aggregation and fibril formation induced by detergent treatments of cellular prion protein.Biochemical and structural studies of the prion protein polymorphism.Engineering the prion protein using chemical synthesis.Cell surface accumulation of a truncated transmembrane prion protein in Gerstmann-Straussler-Scheinker disease P102L.Prion rods contain an inert polysaccharide scaffold.The role of helix 1 aspartates and salt bridges in the stability and conversion of prion protein.The role of electrostatic interaction in triggering the unraveling of stable helix 1 in normal prion protein. A molecular dynamics simulation investigation.Assembly of natural and recombinant prion protein into fibrils.Design of peptides undergoing self-catalytic alpha-to-beta transition and amyloidogenesis.Protease-resistant and detergent-insoluble prion protein is not necessarily associated with prion infectivity.Structural intermediates in the putative pathway from the cellular prion protein to the pathogenic form.
P2860
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P2860
Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform
description
1995 nî lūn-bûn
@nan
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Prion protein (PrP) synthetic ...... perties of the scrapie isoform
@ast
Prion protein (PrP) synthetic ...... perties of the scrapie isoform
@en
type
label
Prion protein (PrP) synthetic ...... perties of the scrapie isoform
@ast
Prion protein (PrP) synthetic ...... perties of the scrapie isoform
@en
prefLabel
Prion protein (PrP) synthetic ...... perties of the scrapie isoform
@ast
Prion protein (PrP) synthetic ...... perties of the scrapie isoform
@en
P2093
P2860
P356
P1476
Prion protein (PrP) synthetic ...... perties of the scrapie isoform
@en
P2093
Baldwin MA
Blochberger TC
Griffith OH
P2860
P304
11160-11164
P356
10.1073/PNAS.92.24.11160
P407
P577
1995-11-01T00:00:00Z