NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases. - Wikidata - wikimedia - TriplyDB

NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases.

NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases.

http://www.wikidata.org/entity/Q33834313

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Targeting JAK2 in the therapy of myeloproliferative neoplasms Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4 Signaling and stress: The redox landscape in NOS2 biology H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling.Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells.Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions.Novel roles of reactive oxygen species in the pathogenesis of acute myeloid leukemia.Kinase domain mutations confer resistance to novel inhibitors targeting JAK2V617F in myeloproliferative neoplasms.Targeting myristoylated alanine-rich C kinase substrate phosphorylation site domain in lung cancer. Mechanisms and therapeutic implications.A key role for NOX4 in epithelial cell death during development of lung fibrosis.The JAK2V617F oncogene requires expression of inducible phosphofructokinase/fructose-bisphosphatase 3 for cell growth and increased metabolic activity Redox signaling at invasive microdomains in cancer cells.A ROS-Activatable Agent Elicits Homologous Recombination DNA Repair and Synergizes with Pathway Compounds Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells.Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis.A peptide that inhibits function of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis.A NOX2/Egr-1/Fyn pathway delineates new targets for TKI-resistant malignancies Redox control of leukemia: from molecular mechanisms to therapeutic opportunities.SAP domain-dependent Mkl1 signaling stimulates proliferation and cell migration by induction of a distinct gene set indicative of poor prognosis in breast cancer patients.Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia.Never-ageing cellular senescence Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis.Aiding and abetting roles of NOX oxidases in cellular transformation.Oxidative metabolism in cancer: A STAT affair?ROS signalling, NADPH oxidases and cancer.Cyclin D1 unbalances the redox status controlling cell adhesion, migration, and drug resistance in myeloma cells.NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells.Jab1/Csn5-Thioredoxin Signaling in Relapsed Acute Monocytic Leukemia under Oxidative Stress.FLT3-driven redox-modulation of Ezrin regulates leukaemic cell migration.Dietary phenolic acids act as effective antioxidants in membrane models and in cultured cells, exhibiting proapoptotic effects in leukaemia cells Paradoxical roles of dual oxidases in cancer biology.Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia.Acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming.NCF2/p67phox: A novel player in the anti-apoptotic functions of p53.Alterations in the Reactive Oxygen Species in Peripheral Blood of Chronic Myeloid Leukaemia Patients from Northern India.MARCKS promotes invasion and is associated with biochemical recurrence in prostate cancer.A novel predictor of cancer malignancy: up-regulation of myristoylated alanine-rich C kinase substrate phosphorylation in lung cancer.Role of NOX2 for leukaemic expansion in a murine model of BCR-ABL1(+) leukaemia.NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells.Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML.

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NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases.

http://www.wikidata.org/entity/Q33834313

description

2010 nî lūn-bûn

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2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

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name

NADPH oxidases regulate cell g ...... by oncogenic tyrosine kinases.

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NADPH oxidases regulate cell g ...... by oncogenic tyrosine kinases.

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type

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NADPH oxidases regulate cell g ...... by oncogenic tyrosine kinases.

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NADPH oxidases regulate cell g ...... by oncogenic tyrosine kinases.

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NADPH oxidases regulate cell g ...... by oncogenic tyrosine kinases.

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NADPH oxidases regulate cell g ...... by oncogenic tyrosine kinases.

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NADPH oxidases regulate cell g ...... by oncogenic tyrosine kinases.

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J D Griffin

http://www.w3.org/2001/XMLSchema#string

M M Reddy

http://www.w3.org/2001/XMLSchema#string

M S Fernandes

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M Sattler

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R L Levine

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R Salgia

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P2860

Cell transformation by the superoxide-generating oxidase Mox1

Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase

NOX enzymes and the biology of reactive oxygen

Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation.

Cross-talk unfolded: MARCKS proteins.

Targeting mutated tyrosine kinases in the therapy of myeloid leukaemias.

Mitochondrial metabolism of reactive oxygen species.

Novel targeted therapies to overcome imatinib mesylate resistance in chronic myeloid leukemia (CML).

The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes

Regulation of Nox and Duox enzymatic activity and expression

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10.1038/LEU.2010.263

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2

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25

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1000863387

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