Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
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The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesisPicomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus.Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine releaseDown-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Presenilin-1 processing of ErbB4 in fetal type II cells is necessary for control of fetal lung maturation.Pathological and physiological functions of presenilins.Amyloid-β as a modulator of synaptic plasticityNeuronal death in Alzheimer's disease and therapeutic opportunities.Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved.The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloidUnique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease.Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.gamma-Secretase: a multifaceted regulator of angiogenesisPresenilins: members of the gamma-secretase quartets, but part-time soloists too.Signature amyloid β profiles are produced by different γ-secretase complexes.The structure and function of Alzheimer's gamma secretase enzyme complex.The many substrates of presenilin/γ-secretase.Proteolytic cleavage of Notch: "HIT and RUN".Ca2+ dysfunction in neurodegenerative disorders: Alzheimer's disease.Lessons from genome-wide association studies findings in Alzheimer's disease.Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's diseaseFrom soluble aβ to progressive aβ aggregation: could prion-like templated misfolding play a role?Biological function of Presenilin and its role in AD pathogenesisNeuregulin-ErbB4 signaling in the developing lung alveolus: a brief review.Dissociated presenilin-1 and TACE processing of ErbB4 in lung alveolar type II cell differentiation.Thapsigargin affects presenilin-2 but not presenilin-1 regulation in SK-N-BE cells.Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer's disease.Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration.Identification of gamma-secretase inhibitor potency determinants on presenilin.A pathogenic p.His169Asn mutation associated with early-onset Alzheimer's disease
P2860
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P2860
Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Dissociated phenotypes in pres ...... lly distinct gamma-secretases.
@ast
Dissociated phenotypes in pres ...... lly distinct gamma-secretases.
@en
type
label
Dissociated phenotypes in pres ...... lly distinct gamma-secretases.
@ast
Dissociated phenotypes in pres ...... lly distinct gamma-secretases.
@en
prefLabel
Dissociated phenotypes in pres ...... lly distinct gamma-secretases.
@ast
Dissociated phenotypes in pres ...... lly distinct gamma-secretases.
@en
P2093
P2860
P356
P1476
Dissociated phenotypes in pres ...... lly distinct gamma-secretases.
@en
P2093
Bob Strome
Chris Ebeling
David Westaway
George A Carlson
Georges Levesque
Heather Pelly
Janaky Coomaraswamy
M Azhar Chishti
Matthew J Mazzella
P2860
P304
P356
10.1073/PNAS.0500940102
P407
P577
2005-06-10T00:00:00Z