Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem.
about
A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPasesPhosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activityStructure-function studies of the G-domain from human gem, a novel small G-proteinA specific tryptophan in the I-II linker is a key determinant of beta-subunit binding and modulation in Ca(V)2.3 calcium channelsNeuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) controls the sorting of newly synthesized Ca(V)1.2 calcium channelsRegulation of voltage-gated calcium channel activity by the Rem and Rad GTPasesThe GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathwayRegulation of calcium channels in smooth muscle: new insights into the role of myosin light chain kinaseMolecular mechanisms of activity-dependent changes in dendritic morphology: role of RGK proteinsL-type calcium channel targeting and local signalling in cardiac myocytesStructure-function of proteins interacting with the α1 pore-forming subunit of high-voltage-activated calcium channelsSmall G proteins in the cardiovascular system: physiological and pathological aspectsActivity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIαStructure of the GDP-bound G domain of the RGK protein Rem2BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosisNew insights into regulation of proteome and polysaccharide in cell wall of Elsholtzia splendens in response to copper stressRab3-interacting molecule gamma isoforms lacking the Rab3-binding domain induce long lasting currents but block neurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca2+ channelsArf-1 (ADP-ribosylation factor-1) is involved in the activation of a mammalian Na+-selective currentPiccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis¹H, ¹³C, and ¹⁵N backbone resonance assignments of the 37 kDa voltage-gated Ca²⁺ channel β4 subunit core SH3-GK domains.Homodimerization of the Src homology 3 domain of the calcium channel β-subunit drives dynamin-dependent endocytosis.The ß subunit of voltage-gated Ca2+ channelsComprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout miceDirect inhibition of P/Q-type voltage-gated Ca2+ channels by Gem does not require a direct Gem/Cavbeta interactionAtypical properties of a conventional calcium channel beta subunit from the platyhelminth Schistosoma mansoni.Ablation of Ca2+ channel beta3 subunit leads to enhanced N-methyl-D-aspartate receptor-dependent long term potentiation and improved long term memoryAncient origins of RGK protein function: modulation of voltage-gated calcium channels preceded the protostome and deuterostome split.The beta subunit of voltage-gated Ca2+ channels interacts with and regulates the activity of a novel isoform of Pax6.Differential effects of RGK proteins on L-type channel function in adult mouse skeletal muscleHuman RAS superfamily proteins and related GTPases.Regulation of high-voltage-activated Ca(2+) channel function, trafficking, and membrane stability by auxiliary subunits.Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation.The Cavβ1a subunit regulates gene expression and suppresses myogenin in muscle progenitor cells.Both the C-terminal polylysine region and the farnesylation of K-RasB are important for its specific interaction with calmodulinRem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents.Gonadotropin-releasing hormone receptor-coupled gene network organization.High expression of GEM and EDNRA is associated with metastasis and poor outcome in patients with advanced bladder cancer.Molecular mechanisms, and selective pharmacological rescue, of Rem-inhibited CaV1.2 channels in heart.Estrogen receptor β and its domains interact with casein kinase 2, phosphokinase C, and N-myristoylation sites of mitochondrial and nuclear proteins in mouse brain.Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels.
P2860
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P2860
Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem.
@ast
Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem.
@en
type
label
Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem.
@ast
Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem.
@en
prefLabel
Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem.
@ast
Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem.
@en
P2093
P356
P1433
P1476
Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem.
@en
P2093
Nagashima K
Shibasaki T
Takahashi K
P2888
P304
P356
10.1038/35079621
P407
P577
2001-06-01T00:00:00Z
P6179
1028677537