Mitochondrial uncoupling as a target for drug development for the treatment of obesity.
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Variation in the link between oxygen consumption and ATP production, and its relevance for animal performanceBrowning of white adipose tissue uncouples glucose uptake from insulin signalingMitochondrial proton and electron leaksMitochondrial dynamics in diabetic cardiomyopathyIntracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomaliesThe basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3UCP4 overexpression improves fatty acid oxidation and insulin sensitivity in L6 myocytesDerivatives of rhodamine 19 as mild mitochondria-targeted cationic uncouplersMitochondria-targeted dodecyltriphenylphosphonium (C12TPP) combats high-fat-diet-induced obesity in miceHigh-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db miceUncoupling protein-2 decreases the lipogenic actions of ghrelinMitochondrial uncoupling and lifespan.2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity and risk of deathA patient with Graves' disease who survived despite developing thyroid storm and lactic acidosis.Antioxidants, Oxyrase, and mitochondrial uncoupler 2,4-dinitrophenol improved postthaw survival of rhesus monkey sperm from ejaculates with low cryosurvival.N-terminally glutamate-substituted analogue of gramicidin A as protonophore and selective mitochondrial uncoupler.Pediatric fatality following ingestion of dinitrophenol: postmortem identification of a "dietary supplement".The mitochondrial uncoupler 2,4-dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia.Penetrating cations enhance uncoupling activity of anionic protonophores in mitochondriaDamaged mitochondria in Fanconi anemia - an isolated event or a general phenomenon?Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice.The Ribosomal Protein-Mdm2-p53 Pathway and Energy Metabolism: Bridging the Gap between Feast and Famine.A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling.Emerging antiobesity drugs.Acute stimulation of white adipocyte respiration by PKA-induced lipolysisA fundamental system of cellular energy homeostasis regulated by PGC-1alphaPolyunsaturated Fatty Acids Attenuate Diet Induced Obesity and Insulin Resistance, Modulating Mitochondrial Respiratory Uncoupling in Rat Skeletal Muscle.Therapeutic prospects of metabolically active brown adipose tissue in humans.Inhibitors of metabolism rescue cell death in Huntington's disease models.The role of mitochondria in the pathogenesis of type 2 diabetesRussian roulette with unlicensed fat-burner drug 2,4-dinitrophenol (DNP): evidence from a multidisciplinary study of the internet, bodybuilding supplements and DNP users.Mitochondrial dysfunction in white adipose tissue.Safety of obesity drugs.The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic.Canine obesity: an overview.Physiological aspects of energy metabolism and gastrointestinal effects of carbohydrates.Mitochondrial Ca2+, the secret behind the function of uncoupling proteins 2 and 3?Mitochondria as pharmacological targets: the discovery of novel anti-obesity mitochondrial uncouplers from Africa's medicinal plants.Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levelsMitochondrial (dys)function in adipocyte (de)differentiation and systemic metabolic alterations.
P2860
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P2860
Mitochondrial uncoupling as a target for drug development for the treatment of obesity.
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Mitochondrial uncoupling as a target for drug development for the treatment of obesity.
@ast
Mitochondrial uncoupling as a target for drug development for the treatment of obesity.
@en
type
label
Mitochondrial uncoupling as a target for drug development for the treatment of obesity.
@ast
Mitochondrial uncoupling as a target for drug development for the treatment of obesity.
@en
prefLabel
Mitochondrial uncoupling as a target for drug development for the treatment of obesity.
@ast
Mitochondrial uncoupling as a target for drug development for the treatment of obesity.
@en
P2093
P2860
P1433
P1476
Mitochondrial uncoupling as a target for drug development for the treatment of obesity.
@en
P2093
J A Harper
K Dickinson
P2860
P304
P356
10.1046/J.1467-789X.2001.00043.X
P577
2001-11-01T00:00:00Z