Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.
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Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activityRegulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbetaRegulation of glutathione synthesisEndotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammationRetinoid-xenobiotic interactions: the Ying and the YangRegulation of the nongenomic actions of retinoid X receptor-α by targeting the coregulator-binding sitesInhibition of Carrageenan-Induced Cutaneous Inflammation by PPAR Agonists Is Dependent on Hepatocyte-Specific Retinoid X ReceptorAlphaMonogenic dyslipidemias: window on determinants of plasma lipoprotein metabolismSexually dimorphic genome-wide binding of retinoid X receptor alpha (RXRα) determines male-female differences in the expression of hepatic lipid processing genes in miceInterleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependentLipopolysaccharide represses cholesterol 7-alpha hydroxylase and induces binding activity to the bile acid response element IIHepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasisHepatocyte RXRalpha deficiency in matured and aged mice: impact on the expression of cancer-related hepatic genes in a gender-specific mannerDeregulation of growth factor, circadian clock, and cell cycle signaling in regenerating hepatocyte RXRalpha-deficient mouse liversComparative analysis of acute and chronic corticosteroid pharmacogenomic effects in rat liver: transcriptional dynamics and regulatory structures.CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal models.Orphan nuclear receptors: the exotics of xenobiotics.Retinoid pathway and cancer therapeuticsIdentification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor.Function annotation of hepatic retinoid x receptor α based on genome-wide DNA binding and transcriptome profilingDrug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models.The role of retinoic acid in hepatic lipid homeostasis defined by genomic binding and transcriptome profilingPredicting tissue specific transcription factor binding sites.RXR activators molecular signalling: involvement of a PPAR alpha-dependent pathway in the liver and kidney, evidence for an alternative pathway in the heartDeficiency of Capicua disrupts bile acid homeostasis.Liver-specific γ-glutamyl carboxylase-deficient mice display bleeding diathesis and short life span.Drug-activated nuclear receptors CAR and PXR.MiR-22-silenced cyclin A expression in colon and liver cancer cells is regulated by bile acid receptor.Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity.Alteration of hepatic nuclear receptor-mediated signaling pathways in hepatitis C virus patients with and without a history of alcohol drinking.Rosiglitazone attenuates suppression of RXRalpha-dependent gene expression in inflamed liver.Application of back propagation artificial neural network on genetic variants in adiponectin ADIPOQ, peroxisome proliferator-activated receptor-γ, and retinoid X receptor-α genes and type 2 diabetes risk in a Chinese Han populationA role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections.Targeting truncated RXRα for cancer therapy.Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).Molecular pathways: current role and future directions of the retinoic acid pathway in cancer prevention and treatmentGenomic profiling in nuclear receptor-mediated toxicity.Role of PPARs and Retinoid X Receptors in the Regulation of Lung Maturation and DevelopmentRecent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Hepatocyte RXR alpha deletion in mice leads to inhibition of angiogenesis.
P2860
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P2860
Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Hepatocyte-specific mutation e ...... ogical processes in the liver.
@ast
Hepatocyte-specific mutation e ...... ogical processes in the liver.
@en
type
label
Hepatocyte-specific mutation e ...... ogical processes in the liver.
@ast
Hepatocyte-specific mutation e ...... ogical processes in the liver.
@en
prefLabel
Hepatocyte-specific mutation e ...... ogical processes in the liver.
@ast
Hepatocyte-specific mutation e ...... ogical processes in the liver.
@en
P2093
P2860
P50
P1476
Hepatocyte-specific mutation e ...... logical processes in the liver
@en
P2093
T Hung-Po Chen
P2860
P304
P356
10.1128/MCB.20.12.4436-4444.2000
P407
P577
2000-06-01T00:00:00Z