Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway.
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The Roles of NDR Protein Kinases in Hippo SignallingLocal tumour hyperthermia as immunotherapy for metastatic cancer.Involvement of YAP, TAZ and HSP90 in contact guidance and intercellular junction formation in corneal epithelial cellsTargeting HSP90-HDAC6 Regulating Network Implicates Precision Treatment of Breast Cancer.Yes-associated protein expression in head and neck squamous cell carcinoma nodal metastasisCheckpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells.FGF8 promotes colorectal cancer growth and metastasis by activating YAP1.17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway.Hsp90 molecular chaperone inhibitors: are we there yet?FRMD4A upregulation in human squamous cell carcinoma promotes tumor growth and metastasis and is associated with poor prognosis.TAZ Protein Accumulation Is Negatively Regulated by YAP Abundance in Mammalian Cells.Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZLoss of large tumor suppressor 1 promotes growth and metastasis of gastric cancer cells through upregulation of the YAP signalingMethylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis.Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones.Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors.LATS1 suppresses proliferation and invasion of cervical cancer.Mammalian Hippo pathway: from development to cancer and beyond.Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling.Snail nuclear transport: the gateways regulating epithelial-to-mesenchymal transition?HSP90AB1: Helping the good and the bad.LATS2 induced by TNF-alpha and inhibited cell proliferation and invasion by phosphorylating YAP in oral squamous cell carcinoma.The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway.Cyclin A2 regulates homologous recombination DNA repair and sensitivity to DNA damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors in human breast cancer cells.The polarity protein Angiomotin p130 controls dendritic spine maturation.miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis.Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells.The role of YAP/TAZ activity in cancer metabolic reprogrammingCyclin A2 regulates symmetrical mitotic spindle formation and centrosome amplification in human colon cancer cells
P2860
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P2860
Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway.
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Heat shock protein 90 inhibiti ...... ippo tumor suppressor pathway.
@ast
Heat shock protein 90 inhibiti ...... ippo tumor suppressor pathway.
@en
Heat shock protein 90 inhibiti ...... ippo tumor suppressor pathway.
@nl
type
label
Heat shock protein 90 inhibiti ...... ippo tumor suppressor pathway.
@ast
Heat shock protein 90 inhibiti ...... ippo tumor suppressor pathway.
@en
Heat shock protein 90 inhibiti ...... ippo tumor suppressor pathway.
@nl
prefLabel
Heat shock protein 90 inhibiti ...... ippo tumor suppressor pathway.
@ast
Heat shock protein 90 inhibiti ...... ippo tumor suppressor pathway.
@en
Heat shock protein 90 inhibiti ...... ippo tumor suppressor pathway.
@nl
P2093
P2860
P1433
P1476
Heat shock protein 90 inhibiti ...... hippo tumor suppressor pathway
@en
P2093
Catherine J Huntoon
Karen S Flatten
Kevin L Peterson
Larry M Karnitz
Monica D Nye
Paul Haluska
P2860
P304
P356
10.1158/0008-5472.CAN-10-1345
P407
P577
2010-09-14T00:00:00Z