Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development. - Wikidata - wikimedia - TriplyDB

Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.

Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.

http://www.wikidata.org/entity/Q34274334

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Out of balance: R-loops in human disease Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair DNA polymerase ε and its roles in genome stability Ribonucleotides in bacterial DNA The enemy within: endogenous retroelements and autoimmune disease RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA A 660-Kb deletion with antagonistic effects on fertility and milk production segregates at high frequency in Nordic Red cattle: additional evidence for the common occurrence of balancing selection in livestock RNase H2 roles in genome integrity revealed by unlinking its activities Structure-function analysis of ribonucleotide bypass by B family DNA replicases Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2{middle dot}DNA and Top2{middle dot}RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)Crystal structure of RNase H3–substrate complex reveals parallel evolution of RNA/DNA hybrid recognition Structural Impact of Single Ribonucleotide Residues in DNA DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair Redundancy in ribonucleotide excision repair: Competition, compensation, and cooperation Lagging-strand replication shapes the mutational landscape of the genome Topoisomerase I alone is sufficient to produce short DNA deletions and can also reverse nicks at ribonucleotide sites Eukaryotic genome instability in light of asymmetric DNA replication Variations in brain DNA Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity The deletion of rnhB in Mycobacterium smegmatis does not affect the level of RNase HII substrates or influence genome stability Mouse models for Aicardi-Goutières syndrome provide clues to the molecular pathogenesis of systemic autoimmunity DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides Ribonucleotides in DNA: Origins, repair and consequences Role of N-terminal extension of Bacillus stearothermophilus RNase H2 and C-terminal extension of Thermotoga maritima RNase H2.Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity.Aicardi-Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion Processing ribonucleotides incorporated during eukaryotic DNA replication.Investigating the mechanisms of ribonucleotide excision repair in Escherichia coli Base excision repair: a critical player in many games How the misincorporation of ribonucleotides into genomic DNA can be both harmful and helpful to cells Causes and consequences of replication stress.SAMHD1 prevents autoimmunity by maintaining genome stability.Genome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondria Ribonuclease H2 in health and disease.Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing.Aicardi-Goutières syndrome and the type I interferonopathies.Identification of small-molecule inhibitors of the ribonuclease H2 enzyme.Identification of host proteins interacting with the integrin-like A domain of Toxoplasma gondii micronemal protein MIC2 by yeast-two-hybrid screening.

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P2860

Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.

http://www.wikidata.org/entity/Q34274334

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2012 nî lūn-bûn

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2012 թուականի Մայիսին հրատարակուած գիտական յօդուած

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P2860

The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conserved

A role for ATR in the DNA damage-induced phosphorylation of p53

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

The RNA worlds in context

Initial sequencing and comparative analysis of the mouse genome

The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutières syndrome defects

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

Trex1 prevents cell-intrinsic initiation of autoimmunity

Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex

Polymerase dynamics at the eukaryotic DNA replication fork

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