T-cell receptor:CD3 down-regulation is a selected in vivo function of simian immunodeficiency virus Nef but is not sufficient for effective viral replication in rhesus macaques.
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Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRζ fragmentsInefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infectionPrimary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication.MLV glycosylated-Gag is an infectivity factor that rescues Nef-deficient HIV-1.Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41.Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptorsCooperative interactions of simian immunodeficiency virus Nef, AP-2, and CD3-zeta mediate the selective induction of T-cell receptor-CD3 endocytosis.Pathogenic effects of human herpesvirus 6 in human lymphoid tissue ex vivo.T cell interleukin-15 surface expression in chimpanzees infected with human immunodeficiency virus.Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles.Nef-mediated MHC class I down-regulation unmasks clonal differences in virus suppression by SIV-specific CD8(+) T cells independent of IFN-gamma and CD107a responsesThe inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses.Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms.The activity of Nef on HIV-1 infectivityComprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques.Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques.The SCHOOL of nature: IV. Learning from viruses.Interactions between SIVNef, SIVGagPol and Alix correlate with viral replication and progression to AIDS in rhesus macaques.Thyroid associated ophthalmopathy: evidence for CD4(+) gammadelta T cells; de novo differentiation of RFD7(+) macrophages, but not of RFD1(+) dendritic cells; and loss of gammadelta and alphabeta T cell receptor expression.
P2860
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P2860
T-cell receptor:CD3 down-regulation is a selected in vivo function of simian immunodeficiency virus Nef but is not sufficient for effective viral replication in rhesus macaques.
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2002 nî lūn-bûn
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2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
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2002年論文
@zh-mo
2002年論文
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2002年论文
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name
T-cell receptor:CD3 down-regul ...... eplication in rhesus macaques.
@ast
T-cell receptor:CD3 down-regul ...... eplication in rhesus macaques.
@en
T-cell receptor:CD3 down-regul ...... eplication in rhesus macaques.
@nl
type
label
T-cell receptor:CD3 down-regul ...... eplication in rhesus macaques.
@ast
T-cell receptor:CD3 down-regul ...... eplication in rhesus macaques.
@en
T-cell receptor:CD3 down-regul ...... eplication in rhesus macaques.
@nl
prefLabel
T-cell receptor:CD3 down-regul ...... eplication in rhesus macaques.
@ast
T-cell receptor:CD3 down-regul ...... eplication in rhesus macaques.
@en
T-cell receptor:CD3 down-regul ...... eplication in rhesus macaques.
@nl
P2093
P2860
P50
P1433
P1476
T-cell receptor:CD3 down-regul ...... eplication in rhesus macaques.
@en
P2093
Ajit Janardhan
Jacek Skowronski
Nicole Stolte
Peter Ten Haaft
P2860
P304
12360-12364
P356
10.1128/JVI.76.23.12360-12364.2002
P407
P577
2002-12-01T00:00:00Z