Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia - Wikidata - wikimedia - TriplyDB

Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia

Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia

http://www.wikidata.org/entity/Q34488469

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Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2 A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription New insight into the molecular mechanisms of MLL-associated leukemia The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein Genomic profiling of B-progenitor acute lymphoblastic leukemia Animal models of leukemia: any closer to the real thing?Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.BET domain co-regulators in obesity, inflammation and cancer Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy Structure of AF3p21, a new member of mixed lineage leukemia (MLL) fusion partner proteins-implication for MLL-induced leukemogenesis.Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4 Transcriptional regulation of BRD7 expression by Sp1 and c-Myc.Intrinsic structural disorder confers cellular viability on oncogenic fusion proteins Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell lymphomagenesis.E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia.Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis.A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9 Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes.MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisom MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia.Genetic lesions and perturbation of chromatin architecture: a road to cell transformation.Common themes in the pathogenesis of acute myeloid leukemia.Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins.Adenovirus E1A: remodelling the host cell, a life or death experience.Bromodomain coactivators in cancer, obesity, type 2 diabetes, and inflammation Flt3 does not play a critical role in murine myeloid leukemias induced by MLL fusion genes.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases.MLL fusions: pathways to leukemia

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Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia

http://www.wikidata.org/entity/Q34488469

description

2000 nî lūn-bûn

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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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Chromatin-related properties o ...... evolves into myeloid leukemia

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Chromatin-related properties o ...... evolves into myeloid leukemia

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Chromatin-related properties o ...... evolves into myeloid leukemia

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Chromatin-related properties o ...... evolves into myeloid leukemia

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Chromatin-related properties o ...... evolves into myeloid leukemia

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Chromatin-related properties o ...... evolves into myeloid leukemia

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prefLabel

Chromatin-related properties o ...... evolves into myeloid leukemia

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Chromatin-related properties o ...... evolves into myeloid leukemia

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Chromatin-related properties o ...... evolves into myeloid leukemia

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The EMBO Journal

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Chromatin-related properties o ...... evolves into myeloid leukemia

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P2860

Structure and ligand of a histone acetyltransferase bromodomain

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins

Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

The transcriptional coactivators p300 and CBP are histone acetyltransferases

The CBP co-activator is a histone acetyltransferase

The bromodomain: a chromatin-targeting module?

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations

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