Seeking a mechanism of action for the novel anticonvulsant lacosamide.
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Lacosamide as treatment for partial epilepsy: mechanisms of action, pharmacology, effects, and safetyIon channels as drug targets in central nervous system disordersLacosamide as a new treatment option in status epilepticusSpecific binding of lacosamide to collapsin response mediator protein 2 (CRMP2) and direct impairment of its canonical function: implications for the therapeutic potential of lacosamideLacosamide: a new approach to target voltage-gated sodium currents in epileptic disordersLacosamide: pharmacology, mechanisms of action and pooled efficacy and safety data in partial-onset seizures.Liquid chromatography-tandem mass spectrometry for quantification of lacosamide, an antiepileptic drug, in rat plasma and its application to pharmacokinetic study.The structure-activity relationship of the 3-oxy site in the anticonvulsant (R)-N-benzyl 2-acetamido-3-methoxypropionamide.In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivationPrevention of posttraumatic axon sprouting by blocking collapsin response mediator protein 2-mediated neurite outgrowth and tubulin polymerization.Lacosamide.Lacosamide: a review of preclinical properties.Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures.Emerging drugs for epilepsy.VOLTAGE-GATED CALCIUM CHANNELS ARE NOT AFFECTED BY THE NOVEL ANTI-EPILEPTIC DRUG LACOSAMIDE.Perspectives on treatment options for mesial temporal lobe epilepsy with hippocampal sclerosis.Antinociceptive efficacy of lacosamide in the monosodium iodoacetate rat model for osteoarthritis pain.Safety of lacosamide in children with refractory partial epilepsy.Post-translational modifications of voltage-gated sodium channels in chronic pain syndromesOpening Pandora's jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders.Voltage-gated sodium channel blockers for the treatment of neuropathic pain.CRMP2 protein SUMOylation modulates NaV1.7 channel trafficking.Clinical perspectives on lacosamideAdvances in diagnostic and treatment options in patients with fibromyalgia syndromeBlock of human cardiac sodium channels by lacosamide: evidence for slow drug binding along the activation pathway.Lacosamide for pain.What is the evidence to use new intravenous AEDs in status epilepticus?Lacosamide for the treatment of epilepsy.Emerging treatment for chronic migraine and refractory chronic migraine.Lacosamide in patients with pharmacoresistant epilepsy.Lacosamide: a review of its use as adjunctive therapy in the management of partial-onset seizures.Pharmacokinetics, brain distribution, and plasma protein binding of the antiepileptic drug lacosamide in rats.Intravenous and Intramuscular Formulations of Antiseizure Drugs in the Treatment of Epilepsy.Cav 2.3 (R-type) calcium channels are critical for mediating anticonvulsive and neuroprotective properties of lamotrigine in vivo.Synergism of lacosamide with established antiepileptic drugs in the 6-Hz seizure model in mice.Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels.Effects of the novel antiepileptic drug lacosamide on the development of amygdala kindling in rats.Activity of the anticonvulsant lacosamide in experimental and human epilepsy via selective effects on slow Na+ channel inactivation.Treatment with lacosamide impedes generalized seizures in a rodent model of cortical dysplasia.Differential effects of sodium channel blockers on in vitro induced epileptiform activities.
P2860
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P2860
Seeking a mechanism of action for the novel anticonvulsant lacosamide.
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Seeking a mechanism of action for the novel anticonvulsant lacosamide.
@ast
Seeking a mechanism of action for the novel anticonvulsant lacosamide.
@en
Seeking a mechanism of action for the novel anticonvulsant lacosamide.
@nl
type
label
Seeking a mechanism of action for the novel anticonvulsant lacosamide.
@ast
Seeking a mechanism of action for the novel anticonvulsant lacosamide.
@en
Seeking a mechanism of action for the novel anticonvulsant lacosamide.
@nl
prefLabel
Seeking a mechanism of action for the novel anticonvulsant lacosamide.
@ast
Seeking a mechanism of action for the novel anticonvulsant lacosamide.
@en
Seeking a mechanism of action for the novel anticonvulsant lacosamide.
@nl
P2093
P1433
P1476
Seeking a mechanism of action for the novel anticonvulsant lacosamide
@en
P2093
George Lees
Leanne Coyne
Norma Selve
Thomas Stöhr
P304
P356
10.1016/J.NEUROPHARM.2006.02.002
P577
2006-04-18T00:00:00Z