HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. - Wikidata - wikimedia - TriplyDB

HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription.

HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription.

http://www.wikidata.org/entity/Q34896128

about

The little elongation complex regulates small nuclear RNA transcription Human mediator subunit MED26 functions as a docking site for transcription elongation factors The little elongation complex functions at initiation and elongation phases of snRNA gene transcription P-TEFb goes viral Manipulation of the host protein acetylation network by human immunodeficiency virus type 1 Bromodomain proteins in HIV infection Extracellular vesicles and viruses: Are they close relatives?Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure Rapid transcriptional pulsing dynamics of high expressing retroviral transgenes in embryonic stem cells The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4 AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter The super elongation complex (SEC) and MLL in development and disease.NUCKS1, a novel Tat coactivator, plays a crucial role in HIV-1 replication by increasing Tat-mediated viral transcription on the HIV-1 LTR promoter Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase A Natural Product from Polygonum cuspidatum Sieb. Et Zucc. Promotes Tat-Dependent HIV Latency Reversal through Triggering P-TEFb's Release from 7SK snRNP Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells Negative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeat.Identification of HIV-1 Tat-Associated Proteins Contributing to HIV-1 Transcription and Latency.Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults.Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat 4sUDRB-seq: measuring genomewide transcriptional elongation rates and initiation frequencies within cells.Mechanism and factors that control HIV-1 transcription and latency activation Genetic analysis of the structure and function of 7SK small nuclear ribonucleoprotein (snRNP) in cells.GPS-Prot: a web-based visualization platform for integrating host-pathogen interaction data.LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis.Transcriptional and posttranscriptional regulation of HIV-1 gene expression A gene-specific role for the Ssu72 RNAPII CTD phosphatase in HIV-1 Tat transactivation.Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit.Phenyl-1-Pyridin-2yl-ethanone-based iron chelators increase IκB-α expression, modulate CDK2 and CDK9 activities, and inhibit HIV-1 transcription Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications.The elongation complex components BRD4 and MLLT3/AF9 are transcriptional coactivators of nuclear retinoid receptors.New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).

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HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription.

http://www.wikidata.org/entity/Q34896128

description

2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

HIV-1 Tat and host AFF4 recrui ...... vation of HIV-1 transcription.

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HIV-1 Tat and host AFF4 recrui ...... vation of HIV-1 transcription.

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HIV-1 Tat and host AFF4 recrui ...... vation of HIV-1 transcription.

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HIV-1 Tat and host AFF4 recrui ...... vation of HIV-1 transcription.

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J.MOLCEL.2010.04.013

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HIV-1 Tat and host AFF4 recrui ...... vation of HIV-1 transcription.

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Alma Burlingame

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Joanne Hsu

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Min Liu

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Nanhai He

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Nevan J Krogan

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Qiang Zhou

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Seemay Chou

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Tom Alber

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Yuhua Xue

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P2860

AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)

Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme

An RNA polymerase II elongation factor encoded by the human ELL gene

Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages

Novel mechanism and factor for regulation by HIV-1 Tat

7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

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428-438

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scholarly article

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10.1016/J.MOLCEL.2010.04.013

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3

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38

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2010-05-01T00:00:00Z

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44601172

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20471948

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3085314

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