Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K(Ca)2 channels.
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Novel phenolic inhibitors of small/intermediate-conductance Ca²⁺-activated K⁺ channels, KCa3.1 and KCa2.3Pharmacological gating modulation of small- and intermediate-conductance Ca(2+)-activated K(+) channels (KCa2.x and KCa3.1)NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease.A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo.CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate.Natural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7Trafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca(2+)-activated K(+) channels: a novel target for medicinal chemistry efforts?Protection against cardiac injury by small Ca(2+)-sensitive K(+) channels identified in guinea pig cardiac inner mitochondrial membraneThe therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseasesAromatic-aromatic interactions between residues in KCa3.1 pore helix and S5 transmembrane segment control the channel gating process.Endothelial small-conductance and intermediate-conductance KCa channels: an update on their pharmacology and usefulness as cardiovascular targets.Potassium channels: structures, diseases, and modulators.Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia.Hydrophobic interactions between the S5 segment and the pore helix stabilizes the closed state of Slo2.1 potassium channelsMolecular mechanisms of Slo2 K+ channel closure.The Natural Flavone Acacetin Blocks Small Conductance Ca2+-Activated K+ Channels Stably Expressed in HEK 293 Cells.Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121).Endogenous and Agonist-induced Opening of Mitochondrial Big Versus Small Ca2+-sensitive K+ Channels on Cardiac Cell and Mitochondrial Protection.Identity and function of a cardiac mitochondrial small conductance Ca2+-activated K+ channel splice variant.A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (KCa 2) channels.
P2860
Q28488052-F4EE72B7-D0C2-4BEE-8E24-61B50FBD4354Q28833834-00515E11-D8C7-43FA-893A-C3CA65619EAFQ34293957-E35DA783-E3A9-41C1-A0F7-90DFA990DB4BQ34946861-220E8D0D-E9DA-430C-923B-0F61E8282F4AQ35752533-81B05146-D64F-4C87-881D-ED46F69A94A6Q36159053-251812B5-B45D-4041-879F-6C103C4AAE61Q36269118-6804B682-CBEE-4387-BBFA-9F587AB79A0AQ36501554-B4DD4CE3-99D8-4F8F-BBCE-301004231D46Q37185277-C111DA04-B100-4332-9549-77CA3ABDC0FFQ37727041-8373F163-7D24-4720-A54A-5EA0111CB0BBQ38056312-362D22A9-EEE6-4D8F-BEC4-CBC115ADB63CQ38151974-74870922-18A5-4708-827F-511BCFDE3355Q38201409-5696F03E-643E-46A7-A905-B12F3EF1530DQ38798356-1C5D04B4-FF02-4F2D-8E94-66B3F18F6008Q41600565-57357875-ACA4-4DB5-8BF7-A53C6EAF16CAQ42682122-5845CB97-42D6-40C5-87A5-236E59D2B06FQ46315519-78BA105C-0E62-4B0A-820B-DA6E1D2EC0B6Q46793542-4BFA5692-327F-4943-9D84-738779E04F87Q47100610-D35670E8-0BAC-4961-9CC4-C322DD47BC44Q48326193-D8C18465-462C-4EC4-8BDD-948C0367E916
P2860
Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K(Ca)2 channels.
description
2011 nî lūn-bûn
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2011 թվականի մարտին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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name
Negative gating modulation by ...... ore gating of K(Ca)2 channels.
@ast
Negative gating modulation by ...... ore gating of K(Ca)2 channels.
@en
type
label
Negative gating modulation by ...... ore gating of K(Ca)2 channels.
@ast
Negative gating modulation by ...... ore gating of K(Ca)2 channels.
@en
prefLabel
Negative gating modulation by ...... ore gating of K(Ca)2 channels.
@ast
Negative gating modulation by ...... ore gating of K(Ca)2 channels.
@en
P2093
P2860
P356
P1476
Negative gating modulation by ...... ore gating of K(Ca)2 channels.
@en
P2093
Charlotte Hougaard
David Paul Jenkins
Dorte Strøbæk
Heike Wulff
Marianne L Jensen
Palle Christophersen
Rene Hummel
Ulrik S Sørensen
P2860
P304
P356
10.1124/MOL.110.069807
P577
2011-03-01T00:00:00Z