International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes
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Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicityBiology-inspired microphysiological system approaches to solve the prediction dilemma of substance testingA critical review of neonicotinoid insecticides for developmental neurotoxicityA transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitorsReference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use.Human Induced Pluripotent Stem Cell Derived Neuronal Cells Cultured on Chemically-Defined Hydrogels for Sensitive In Vitro Detection of Botulinum Neurotoxin.Human pluripotent stem cell-derived neural constructs for predicting neural toxicity.Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library.Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration.Stem Cell-Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants.Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assayIn vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities.Adverse outcome pathways: Application to enhance mechanistic understanding of neurotoxicity.Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro.Comparative human and rat neurospheres reveal species differences in chemical effects on neurodevelopmental key events.Adverse outcome pathways: opportunities, limitations and open questionsFrom smoking guns to footprints: mining for critical events of toxicity pathways in transcriptome data.Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk.From the Cover: Developmental Neurotoxicants Disrupt Activity in Cortical Networks on Microelectrode Arrays: Results of Screening 86 Compounds During Neural Network Formation.Whole genome microarray analysis of neural progenitor C17.2 cells during differentiation and validation of 30 neural mRNA biomarkers for estimation of developmental neurotoxicity.Omnisphero: a high-content image analysis (HCA) approach for phenotypic developmental neurotoxicity (DNT) screenings of organoid neurosphere cultures in vitro.Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes.Rotenone exerts developmental neurotoxicity in a human brain spheroid model.Development of the Adverse Outcome Pathway (AOP): Chronic binding of antagonist to N-methyl-d-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities of children.Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods.
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P2860
International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes
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2015 nî lūn-bûn
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2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2015 թվականի հունվարին հրատարակված գիտական հոդված
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年學術文章
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International STakeholder NETw ...... ad map for regulatory purposes
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International STakeholder NETw ...... ad map for regulatory purposes
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type
label
International STakeholder NETw ...... ad map for regulatory purposes
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International STakeholder NETw ...... ad map for regulatory purposes
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International STakeholder NETw ...... ad map for regulatory purposes
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International STakeholder NETw ...... ad map for regulatory purposes
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P2860
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International STakeholder NETw ...... ad map for regulatory purposes
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P2093
Aldert Piersma
Anna Bal-Price
Benoît Schilter
Daniela Oggier
Ellen Fritsche
Enrico Tongiorgi
Eva Rached
Florianne Monnet-Tschudi
Gabriele Schmuck
Helena Hogberg
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P2888
P304
P356
10.1007/S00204-015-1464-2
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2015-01-25T00:00:00Z