Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.
about
Sphingosine-1-Phosphate Receptor-2 Antagonists: Therapeutic Potential and Potential RisksThe broken "Off" switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillanceEvolving concepts in cancer therapy through targeting sphingolipid metabolismCeramide induced mitophagy and tumor suppressionFTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse modelRe-configuration of sphingolipid metabolism by oncogenic transformation.Sphingosine kinase 1 in cancer.An update on the biology of sphingosine 1-phosphate receptors.From the Biology of PP2A to the PADs for Therapy of Hematologic MalignanciesSingle-cell sphingosine kinase activity measurements in primary leukemiaInterdiction of sphingolipid metabolism to improve standard cancer therapies.Moving on up: Second-Line Agents as Initial Treatment for Newly-Diagnosed Patients with Chronic Phase CML.Sphingosine-1-phosphate receptor 2Sphingosine-1-phosphate signaling and its role in disease.Sphingosine kinase 1 as an anticancer therapeutic target.A comparative proteomic study identified LRPPRC and MCM7 as putative actors in imatinib mesylate cross-resistance in Lucena cell line.Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genesSphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.Emerging Role of Sphingosine-1-phosphate in Inflammation, Cancer, and Lymphangiogenesis.Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progressionPhosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation.Oncogenic properties of sphingosine kinases in haematological malignancies.Protein phosphatase 2A: a target for anticancer therapy.Changes in molecular biology of chronic myeloid leukemia in tyrosine kinase inhibitor era.Role of sphingosine 1-phosphate in human pancreatic cancer cells proliferation and migration.Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies.Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1.Analysis of conformational determinants underlying HSP90-kinase interactionTargeting sphingosine-1-phosphate signaling for cancer therapy.Sphingosine 1-phosphate interacts with Survivin pathway to enhance tumorigenesis in cancer cells.MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma.Sphingosine-1-phosphate transporters as targets for cancer therapy.Unexpected profile of sphingolipid contents in blood and bone marrow plasma collected from patients diagnosed with acute myeloid leukemia.Expansion of Sphingosine Kinase and Sphingosine-1-Phosphate Receptor Function in Normal and Cancer Cells: From Membrane Restructuring to Mediation of Estrogen Signaling and Stem Cell Programming.Sphingolipid metabolism in cancer signalling and therapy.Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice.Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry.Bcr-Abl regulation of sphingomyelin synthase 1 reveals a novel oncogenic-driven mechanism of protein up-regulation.Therapeutic potential of apigenin, a plant flavonoid, for imatinib-sensitive and resistant chronic myeloid leukemia cells.
P2860
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P2860
Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
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2011年學術文章
@yue
name
Sphingosine kinase-1 and sphin ...... ion of protein phosphatase 2A.
@ast
Sphingosine kinase-1 and sphin ...... ion of protein phosphatase 2A.
@en
type
label
Sphingosine kinase-1 and sphin ...... ion of protein phosphatase 2A.
@ast
Sphingosine kinase-1 and sphin ...... ion of protein phosphatase 2A.
@en
prefLabel
Sphingosine kinase-1 and sphin ...... ion of protein phosphatase 2A.
@ast
Sphingosine kinase-1 and sphin ...... ion of protein phosphatase 2A.
@en
P2093
P2860
P1433
P1476
Sphingosine kinase-1 and sphin ...... ion of protein phosphatase 2A.
@en
P2093
Arelis Salas
Besim Ogretmen
Can E Senkal
Charles Smith
Christopher R Gault
Daniel Fernandes
Danilo Perrotti
Elif Apohan
Hesham M El-Shewy
Joshua Oaks
P2860
P304
P356
10.1182/BLOOD-2010-08-300772
P407
P577
2011-04-28T00:00:00Z