Telomere inhibition and telomere disruption as processes for drug targeting.
about
DNA and the chromosome - varied targets for chemotherapyControlling the stoichiometry and strand polarity of a tetramolecular G-quadruplex structure by using a DNA origami frame.Targeting human telomerase for cancer therapeutics.Duplex formation at the 5' end affects the quadruplex conformation of the human telomeric repeat overhang in sodium but not in potassium.Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.Examination of the effect of the annealing cation on higher order structures containing guanine or isoguanine repeatsEmulsified BMVC derivative induced filtration for G-quadruplex DNA structural separationCation involvement in telomestatin binding to g-quadruplex DNA.A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands."One ring to bind them all"-part I: the efficiency of the macrocyclic scaffold for g-quadruplex DNA recognition.Polymorphic nucleic Acid binding of bioactive isoquinoline alkaloids and their role in cancer.Interaction of pyrrolobenzodiazepine (PBD) ligands with parallel intermolecular G-quadruplex complex using spectroscopy and ESI-MS.NMR solution structures of LNA (locked nucleic acid) modified quadruplexes.Fluorescent probes for nucleic Acid visualization in fixed and live cells.Recognition of chelerythrine to human telomeric DNA and RNA G-quadruplexes.Naphthyridine tetramer with a pre-organized structure for 1:1 binding to a CGG/CGG sequence.Gas-phase stability of G-quadruplex DNA determined by electrospray ionization tandem mass spectrometry and molecular dynamics simulations.A novel transition pathway of ligand-induced topological conversion from hybrid forms to parallel forms of human telomeric G-quadruplexes.Molecular dynamics simulations and their application to four-stranded DNA.Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing.A hitchhiker's guide to G-quadruplex ligands.HIV-1 nucleocapsid proteins as molecular chaperones for tetramolecular antiparallel G-quadruplex formation.Small molecule modifiers of the microRNA and RNA interference pathway.Structural basis of sodium-potassium exchange of a human telomeric DNA quadruplex without topological conversion.G-Quadruplex binding enantiomers show chiral selective interactions with human telomere.A novel structural derivative of natural alkaloid ellipticine, MDPSQ, induces necrosis in leukemic cells.Binding of G-quadruplex-interactive agents to distinct G-quadruplexes induces different biological effects in MiaPaCa cells.Optimization of the TRAP assay to evaluate specificity of telomerase inhibitors.Inhibitory effect of human telomerase antisense oligodeoxyribonucleotides on the growth of gastric cancer cell lines in variant tumor pathological subtype.Quantitative analysis of small molecule-nucleic acid interactions with a biosensor surface and surface plasmon resonance detection.Identification of G-Quadruplex Inducers Usinga Simple, Inexpensiveand Rapid High Throughput Assay, and TheirInhibition of Human TelomeraseGene function correlates with potential for G4 DNA formation in the human genome.Using Genome Sequence to Enable the Design of Medicines and Chemical Probes.Conformational and electronic effects on the formation of anti cyclobutane pyrimidine dimers in G-quadruplex structures.Stabilization of human telomeric G-quadruplex and inhibition of telomerase activity by propeller-shaped trinuclear Pt(II) complexes.A single-molecule force-spectroscopic study on stabilization of G-quadruplex DNA by a telomerase inhibitor.The Truncated Human Telomeric Sequence forms a Hybrid-Type Intramolecular Mixed Parallel/antiparallel G-quadruplex Structure in K(+) Solution.ESI-MS Investigation of an Equilibrium between a Bimolecular Quadruplex DNA and a Duplex DNA/RNA Hybrid.
P2860
Q24792540-85FAB3B8-5C2A-4495-BD6D-C7E9637F7208Q30549945-84ABC414-35BB-426C-B486-95DF4C39F2AAQ33383955-8AD710A0-B4A7-4E89-A1DB-6F3D64E900C9Q33605084-7884CB49-5686-4CE0-853B-F0B4B9C1B719Q33814333-851D3732-F08F-4247-9C5A-DEF427F7D67FQ33924776-5E697477-4D94-4E3A-B369-14ACB30C35C2Q33946180-078E9707-7F05-4F37-8867-980D6B0BF081Q34026367-0C8647CE-461C-4D53-BB05-E12D735F94A5Q34028382-425A5227-6BE1-40D6-AD84-231AF8E237DEQ34043354-33D89071-044B-4D00-83EF-4000DC504F5FQ34043401-8F33E30A-7A35-4894-9D01-0B78CE65F4C2Q34256936-5158B7CD-EEB5-41AF-8221-A9B0D65EE83EQ34538449-67E8FF08-3272-4632-AD93-FE710643FE1DQ35066396-989D6E4E-188D-41DD-B054-0399FCBA7A87Q35363012-2A31C1CF-1C3C-4DAC-A365-4C546D41ECF1Q35860577-5F94E03B-1E87-4F48-813D-C8950DD43810Q36140908-984C95F4-7DBB-4A03-AB28-21CB2A967E40Q36870524-9E6EC28E-889A-44DA-84E5-CEFDCE665397Q36984621-D3FA0186-10A3-4A82-85E7-75F75B519ECCQ37068421-3F937F49-7115-4E92-90D6-F4AFBB564DC2Q37080928-1B4F4F7D-0731-4244-8F2D-C4A3F3D2A8AAQ37502062-0DAD7CC6-CA27-4D2A-9D81-341217DD4BAAQ37638475-29C532D8-6B87-4A9F-BC5C-63052CE8EEBCQ37701293-1FC82AAD-367E-42BC-83C9-500DFC43F666Q38593886-18E8F39F-5484-4028-99CC-278E34F48EFFQ39752703-EDA640DD-C9B3-4DFA-8E43-30D0C1186E40Q40324868-14FF76F4-3A7F-4A80-B2E1-08771E016816Q40371821-11062293-7366-4330-A293-39E9041B95F0Q40437108-FF935EF2-E6EC-4976-8870-D4066DBEE49DQ41450924-9271D0C1-5C43-4914-BAAC-122846B75ADBQ41630512-491B96B2-48F4-4566-BE15-4BE10D791128Q43056206-8A32CD7F-E235-4049-9157-25BB14763F99Q48263612-5AEA071D-F9DA-470B-ACF9-C7A55A092FE1Q48350237-44A9F352-79C8-4334-80CF-3717399CFEC3Q53509701-7E63264F-BA36-4A42-BF11-5D3E588EB696Q53522805-4389E032-C58A-4986-904F-F1145E1F2C57Q54215648-41CCD149-E6D9-42C3-8DE1-F7264BD788D7Q55060614-41AD543C-A637-4E17-9937-CC34B94D6253
P2860
Telomere inhibition and telomere disruption as processes for drug targeting.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Telomere inhibition and telomere disruption as processes for drug targeting.
@ast
Telomere inhibition and telomere disruption as processes for drug targeting.
@en
type
label
Telomere inhibition and telomere disruption as processes for drug targeting.
@ast
Telomere inhibition and telomere disruption as processes for drug targeting.
@en
prefLabel
Telomere inhibition and telomere disruption as processes for drug targeting.
@ast
Telomere inhibition and telomere disruption as processes for drug targeting.
@en
P1476
Telomere inhibition and telomere disruption as processes for drug targeting.
@en
P2093
Evonne M Rezler
Laurence H Hurley
P304
P356
10.1146/ANNUREV.PHARMTOX.43.100901.135733
P577
2002-01-10T00:00:00Z