A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease
about
Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metforminPeroxisome proliferator activated receptors at the crossroad of obesity, diabetes, and pancreatic cancerMouse models of pancreatic cancerGenetically engineered mouse models of pancreatic adenocarcinomaUtilizing past and present mouse systems to engineer more relevant pancreatic cancer modelsRegulation of Cellular Identity in CancerDifferential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivoLipopolysaccharide represses cholesterol 7-alpha hydroxylase and induces binding activity to the bile acid response element IIEffects of Muclin (Dmbt1) deficiency on the gastrointestinal system.Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedgehog signaling activation.Murine pancreatic tumor cell line TD2 bears the characteristic pattern of genetic changes with two independently amplified gene loci.Identification of a novel murine pancreatic tumour antigen, which elicits antibody responses in patients with pancreatic carcinoma.Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia.Mouse models expressing human carcinoembryonic antigen (CEA) as a transgene: evaluation of CEA-based cancer vaccines.Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia.In vivo disruption of TGF-beta signaling by Smad7 leads to premalignant ductal lesions in the pancreasGenetics and pathology of pancreatic cancer.Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma.The epidermal growth factor receptor inhibitor gefitinib prevents the progression of pancreatic lesions to carcinoma in a conditional LSL-KrasG12D/+ transgenic mouse model.N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruption.Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas.Age-dependent accumulation of recombinant cells in the mouse pancreas revealed by in situ fluorescence imaging.Differential sensitivity of mouse epithelial tissues to the polyomavirus middle T oncogene.Mouse models with modified p53 sequences to study cancer and ageing.Hedgehog/Ras interactions regulate early stages of pancreatic cancer.Live bacteria as the basis for immunotherapies against cancer.Smad4 loss synergizes with TGFα overexpression in promoting pancreatic metaplasia, PanIN development, and fibrosis.Aberrant signaling pathways in pancreatic cancer: a two compartment view.Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between.Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for translational efforts.Ductal pancreatic cancer in humans and mice.Genetically engineered mouse models of pancreatic cancer.Inducible re-expression of p16 in an orthotopic mouse model of pancreatic cancer inhibits lymphangiogenesis and lymphatic metastasisHistological complexities of pancreatic lesions from transgenic mouse models are consistent with biological and morphological heterogeneity of human pancreatic cancer.Integrated one- and two-photon imaging platform reveals clonal expansion as a major driver of mutation load.Targeting signal transduction in pancreatic cancer treatment.Biodistribution and pharmacokinetics of EGFR-targeted thiolated gelatin nanoparticles following systemic administration in pancreatic tumor-bearing mice.Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis.Macropinocytosis of protein is an amino acid supply route in Ras-transformed cellsChallenges and advances in mouse modeling for human pancreatic tumorigenesis and metastasis
P2860
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P2860
A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
A murine tumor progression mod ...... terations of the human disease
@ast
A murine tumor progression mod ...... terations of the human disease
@en
type
label
A murine tumor progression mod ...... terations of the human disease
@ast
A murine tumor progression mod ...... terations of the human disease
@en
prefLabel
A murine tumor progression mod ...... terations of the human disease
@ast
A murine tumor progression mod ...... terations of the human disease
@en
P2093
P2860
P356
P1433
P1476
A murine tumor progression mod ...... terations of the human disease
@en
P2093
Koschnick S
Mattfeldt T
P2860
P304
P356
10.1101/GAD.184701
P577
2001-02-01T00:00:00Z