Assessing helical protein interfaces for inhibitor design.
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Synthetic Peptides as Protein MimicsMulti-Facial, Non-Peptidic α-Helix MimeticsAdding diverse noncanonical backbones to rosetta: enabling peptidomimetic designDifferential Impact of β and γ Residue Preorganization on α/β/γ-Peptide Helix Stability in WaterEnhancement of α-Helix Mimicry by an α/β-Peptide Foldamer via Incorporation of a Dense Ionic Side-Chain ArrayExploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologiesA Strategy for Direct Chemical Activation of the Retinoblastoma ProteinServerification of molecular modeling applications: the Rosetta Online Server that Includes Everyone (ROSIE)Structure-based inhibition of protein-protein interactions.Protein-Protein Interactions Mediated by Helical Tertiary Structure Motifs.Truncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1Comparative α-helicity of cyclic pentapeptides in water.Helix Nucleation by the Smallest Known α-Helix in Water.In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics.Large ring-forming alkylations provide facile access to composite macrocyclesEssential multimeric enzymes in kinetoplastid parasites: A host of potentially druggable protein-protein interactions.Anatomy of β-strands at protein-protein interfaces.A leap into the chemical space of protein-protein interaction inhibitorsComprehensive peptidomimetic libraries targeting protein-protein interactions.Downsizing a human inflammatory protein to a small molecule with equal potency and functionality.Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactionsDesign of libraries targeting protein-protein interfaces.Solid-phase methodology for synthesis of O-alkylated aromatic oligoamide inhibitors of α-helix-mediated protein-protein interactionsComputational analysis of protein-protein interfaces involving an alpha helix: insights for terphenyl-like molecules binding.Rational design of topographical helix mimics as potent inhibitors of protein-protein interactions.Understanding the molecular basis of EGFR kinase domain/MIG-6 peptide recognition complex using computational analysesSelective and potent proteomimetic inhibitors of intracellular protein-protein interactionsHuman immunodeficiency virus-associated dementia: a link between accumulation of viral proteins and neuronal degeneration.State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.Towards more drug-like proteomimetics: two-faced, synthetic α-helix mimetics based on a purine scaffold.High-resolution structures of a heterochiral coiled coilIdentification of a binding site of the human immunodeficiency virus envelope protein gp120 to neuronal-specific tubulinProtein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling.HippDB: a database of readily targeted helical protein-protein interactions.Functional, metal-based crosslinkers for α-helix induction in short peptidesDesign, synthesis, conformational analysis and application of indolizidin-2-one dipeptide mimics.Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics.Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.The Pseudomonas aeruginosa AmrZ C-terminal domain mediates tetramerization and is required for its activator and repressor functions
P2860
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P2860
Assessing helical protein interfaces for inhibitor design.
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Assessing helical protein interfaces for inhibitor design.
@ast
Assessing helical protein interfaces for inhibitor design.
@en
type
label
Assessing helical protein interfaces for inhibitor design.
@ast
Assessing helical protein interfaces for inhibitor design.
@en
prefLabel
Assessing helical protein interfaces for inhibitor design.
@ast
Assessing helical protein interfaces for inhibitor design.
@en
P2093
P2860
P356
P1476
Assessing helical protein interfaces for inhibitor design.
@en
P2093
Andrea L Jochim
Brooke N Bullock
Paramjit S Arora
P2860
P304
14220-14223
P356
10.1021/JA206074J
P407
P577
2011-08-22T00:00:00Z