Metabolic engineering for drug discovery and development.
about
Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discoveryCombinatorial biosynthesis of antitumor indolocarbazole compoundsNeurotoxic alkaloids: saxitoxin and its analogsMarine Invertebrate Metabolites with Anticancer Activities: Solutions to the "Supply Problem"Cnidarians as a source of new marine bioactive compounds--an overview of the last decade and future steps for bioprospectingCrystal Structures and Mutational Analyses of Acyl-CoA Carboxylase β Subunit of Streptomyces coelicolor ,Programming cells by multiplex genome engineering and accelerated evolutionProduction of glucaric acid from a synthetic pathway in recombinant Escherichia coliAnchoring a plant cytochrome P450 via PsaM to the thylakoids in Synechococcus sp. PCC 7002: evidence for light-driven biosynthesisThe phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for lifeSpirotetronate polyketides as leads in drug discovery.Exploring the diversity of complex metabolic networks.Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes.OptORF: Optimal metabolic and regulatory perturbations for metabolic engineering of microbial strains.Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues.Accessorizing natural products: adding to nature's toolbox.Laboratory-evolved mutants of an exogenous global regulator, IrrE from Deinococcus radiodurans, enhance stress tolerances of Escherichia coliNew and highly efficient methodology for screening high-yield strains of cytotoxic deacetylmycoepoxydiene (DAM).A synthetic library of RNA control modules for predictable tuning of gene expression in yeast.Engineering butanol-tolerance in escherichia coli with artificial transcription factor libraries.Synthetic biology.BglBrick vectors and datasheets: A synthetic biology platform for gene expression.Total synthesis of (+)-roxaticin via C-C bond forming transfer hydrogenation: a departure from stoichiometric chiral reagents, auxiliaries, and premetalated nucleophiles in polyketide construction.Antiviral lead compounds from marine sponges.The marine actinomycete genus Salinispora: a model organism for secondary metabolite discoveryNovel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy.Evolution, ecology and the engineered organism: lessons for synthetic biology.Model-driven evaluation of the production potential for growth-coupled products of Escherichia coli.DNA signatures for detecting genetic engineering in bacteria.Protein design for pathway engineeringEngineering transcription factors with novel DNA-binding specificity using comparative genomicsReconstruction of the archaeal isoprenoid ether lipid biosynthesis pathway in Escherichia coli through digeranylgeranylglyceryl phosphate.Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant cultureSynthetic biology: understanding biological design from synthetic circuits.Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes.Modeling and analysis of biopathways dynamics.Perspectives in metabolic engineering: understanding cellular regulation towards the control of metabolic routes.Systems biology of cyanobacterial secondary metabolite production and its role in drug discovery.Recent advances in the biosynthesis of unusual polyketide synthase substrates.Structural modification of herboxidiene by substrate-flexible cytochrome P450 and glycosyltransferase.
P2860
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P2860
Metabolic engineering for drug discovery and development.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Metabolic engineering for drug discovery and development.
@ast
Metabolic engineering for drug discovery and development.
@en
type
label
Metabolic engineering for drug discovery and development.
@ast
Metabolic engineering for drug discovery and development.
@en
prefLabel
Metabolic engineering for drug discovery and development.
@ast
Metabolic engineering for drug discovery and development.
@en
P356
P1476
Metabolic engineering for drug discovery and development.
@en
P2093
Chaitan Khosla
Jay D Keasling
P2888
P304
P356
10.1038/NRD1256
P577
2003-12-01T00:00:00Z