Mutations in the β-tubulin binding site for peloruside A confer resistance by targeting a cleft significant in side chain binding.

Mutations in the β-tubulin binding site for peloruside A confer resistance by targeting a cleft significant in side chain binding.

Item
http://www.wikidata.org/entity/Q35600753
Conformation-activity relationships of polyketide natural products.Rapid access to conformational analogues of (+)-peloruside A.Toward an enantioselective synthesis of (-)-zampanolide: preparation of the C9-C20 regionLow-dose laulimalide represents a novel molecular probe for investigating microtubule organizationSynthesis and Biological Evaluation of 7-Deoxy-Epothilone Analogues.Peloruside, laulimalide, and noscapine interactions with beta-tubulin.Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities.Structural insight into the role of Gln293Met mutation on the Peloruside A/Laulimalide association with αβ-tubulin from molecular dynamics simulations, binding free energy calculations and weak interactions analysis.Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration.Peloruside A: a lead non-taxoid-site microtubule-stabilizing agent with potential activity against cancer, neurodegeneration, and autoimmune disease.Characterizing the laulimalide-peloruside binding site using site-directed mutagenesis of TUB2 in S. cerevisiae.Synthesis and biological activity of 7,8,9-trideoxy- and 7R desTHP-peloruside A.Paclitaxel resistance by random mutagenesis of α-tubulin.
P2860

Mutations in the β-tubulin binding site for peloruside A confer resistance by targeting a cleft significant in side chain binding.

Item
http://www.wikidata.org/entity/Q35600753
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Mutations in the β-tubulin bin ...... ificant in side chain binding.
@ast
Mutations in the β-tubulin bin ...... ificant in side chain binding.
@en
type
label
Mutations in the β-tubulin bin ...... ificant in side chain binding.
@ast
Mutations in the β-tubulin bin ...... ificant in side chain binding.
@en
prefLabel
Mutations in the β-tubulin bin ...... ificant in side chain binding.
@ast
Mutations in the β-tubulin bin ...... ificant in side chain binding.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P577
P5875
P698
P921
P932
P356
P1433
P1476
Mutations in the β-tubulin bin ...... ificant in side chain binding.
@en
P2093
P2860
P304
P31
P356
P433
P478
P577
P5875
P698
P921
P932