Calcium-independent phospholipase A2 localizes in and protects mitochondria during apoptotic induction by staurosporine. - Wikidata - wikimedia - TriplyDB

Calcium-independent phospholipase A2 localizes in and protects mitochondria during apoptotic induction by staurosporine.

Calcium-independent phospholipase A2 localizes in and protects mitochondria during apoptotic induction by staurosporine.

http://www.wikidata.org/entity/Q35691202

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Neurodegeneration with brain iron accumulation: update on pathogenic mechanisms LC/MS characterization of rotenone induced cardiolipin oxidation in human lymphocytes: implications for mitochondrial dysfunction associated with Parkinson's disease Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome Mitochondrial dysfunction in Parkinson's disease The role of peroxidation of mitochondrial membrane phospholipids in pancreatic β -cell failure Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention Maintenance of synaptic stability requires calcium-independent phospholipase A₂ activity Phospholipase A2 biochemistry Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexin Genetic ablation of PLA2G6 in mice leads to cerebellar atrophy characterized by Purkinje cell loss and glial cell activation Cardiolipin remodeling: a regulatory hub for modulating cardiolipin metabolism and function Assessing phospholipase A2 activity toward cardiolipin by mass spectrometry Group VIA phospholipase A2 mitigates palmitate-induced β-cell mitochondrial injury and apoptosis The role of calcium-independent phospholipase A2 in cardiolipin remodeling in the spontaneously hypertensive heart failure rat heart Genetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation.Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death.Protection of pancreatic beta-cells by group VIA phospholipase A(2)-mediated repair of mitochondrial membrane peroxidation.The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR.Brain, blood, and iron: perspectives on the roles of erythrocytes and iron in neurodegeneration.Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype Mitochondrial monolysocardiolipin acyltransferase is elevated in the surviving population of H9c2 cardiac myoblast cells exposed to 2-deoxyglucose-induced apoptosis.Exendin-4 protects mitochondria from reactive oxygen species induced apoptosis in pancreatic Beta cells.A tripeptide Diapin effectively lowers blood glucose levels in male type 2 diabetes mice by increasing blood levels of insulin and GLP-1.Mitochondrial dysfunction and β-cell failure in type 2 diabetes mellitus.Group VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signaling FTY720 normalizes hyperglycemia by stimulating β-cell in vivo regeneration in db/db mice through regulation of cyclin D3 and p57(KIP2).Deficiency of Calcium-Independent Phospholipase A2 Beta Induces Brain Iron Accumulation through Upregulation of Divalent Metal Transporter 1 Disruption of Golgi morphology and altered protein glycosylation in PLA2G6-associated neurodegeneration Calcium-independent phospholipases A2 and their roles in biological processes and diseases.Severe disturbance in the Ca2+ signaling in astrocytes from mouse models of human infantile neuroaxonal dystrophy with mutated Pla2g6 Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction.Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2.Mitochondria: the next (neurode)generation Group VIB Phospholipase A(2) promotes proliferation of INS-1 insulinoma cells and attenuates lipid peroxidation and apoptosis induced by inflammatory cytokines and oxidant agents Decreased iPLA2gamma expression induces lipid peroxidation and cell death and sensitizes cells to oxidant-induced apoptosis Dysfunctional cardiac mitochondrial bioenergetic, lipidomic, and signaling in a murine model of Barth syndrome Review: Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories.Genetic modulation of islet β-cell iPLA₂β expression provides evidence for its impact on β-cell apoptosis and autophagy The role of GSH efflux in staurosporine-induced apoptosis in colonic epithelial cells.Advanced glycation end products inhibit glucose-stimulated insulin secretion through nitric oxide-dependent inhibition of cytochrome c oxidase and adenosine triphosphate synthesis

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P2860

Calcium-independent phospholipase A2 localizes in and protects mitochondria during apoptotic induction by staurosporine.

http://www.wikidata.org/entity/Q35691202

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

Calcium-independent phospholip ...... ic induction by staurosporine.

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Calcium-independent phospholip ...... ic induction by staurosporine.

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type

label

Calcium-independent phospholip ...... ic induction by staurosporine.

@ast

Calcium-independent phospholip ...... ic induction by staurosporine.

@en

prefLabel

Calcium-independent phospholip ...... ic induction by staurosporine.

@ast

Calcium-independent phospholip ...... ic induction by staurosporine.

@en

P1433

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P1433

Journal of Biological Chemistry

P1476

Calcium-independent phospholip ...... ic induction by staurosporine.

@en

P2093

Chunying Zhao

http://www.w3.org/2001/XMLSchema#string

Keying Song

http://www.w3.org/2001/XMLSchema#string

Konstantin Seleznev

http://www.w3.org/2001/XMLSchema#string

Xu Hannah Zhang

http://www.w3.org/2001/XMLSchema#string

Zhongmin Alex Ma

http://www.w3.org/2001/XMLSchema#string

P2860

Molecular characterization of mitochondrial apoptosis-inducing factor

Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

Lysocardiolipin formation and reacylation in isolated rat liver mitochondria

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

Cytochrome c release from mitochondria proceeds by a two-step process.

Pancreatic islets express a Ca2+-independent phospholipase A2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrin

The expanding superfamily of phospholipase A(2) enzymes: classification and characterization

P304

22275-22288

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scholarly article

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10.1074/JBC.M604330200

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31

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281

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2006-05-25T00:00:00Z

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16728389

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apoptotic process

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1829309

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