Rational selection of small molecules that increase transcription through the GAA repeats found in Friedreich's ataxia.
about
New insights into repeat instability: role of RNA•DNA hybridsUnderstanding the genetic and molecular pathogenesis of Friedreich's ataxia through animal and cellular modelsGeneration and characterisation of Friedreich ataxia YG8R mouse fibroblast and neural stem cell modelsDisruption of Higher Order DNA Structures in Friedreich's Ataxia (GAA)n Repeats by PNA or LNA TargetingFlavin adenine dinucleotide rescues the phenotype of frataxin deficiency.Reducing levels of toxic RNA with small moleculesFriedreich ataxia: molecular mechanisms, redox considerations, and therapeutic opportunities.Intracellular iron transport and storage: from molecular mechanisms to health implications.A rapid, noninvasive immunoassay for frataxin: utility in assessment of Friedreich ataxiaSmall molecules affecting transcription in Friedreich ataxiaA GAA repeat expansion reporter model of Friedreich's ataxia recapitulates the genomic context and allows rapid screening of therapeutic compounds.Genome-Engineering Tools to Establish Accurate Reporter Cell Lines That Enable Identification of Therapeutic Strategies to Treat Friedreich's Ataxia.Expanded GAA repeats impede transcription elongation through the FXN gene and induce transcriptional silencing that is restricted to the FXN locus.Advancements in the pathophysiology of Friedreich's Ataxia and new prospects for treatments.Long intronic GAA*TTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia.Lateral-flow immunoassay for the frataxin protein in Friedreich's ataxia patients and carriers.Current and emerging treatment options in the management of Friedreich ataxia.DNA triplex structures in neurodegenerative disorder, Friedreich's ataxia.Microscopic rearrangement of bound minor groove binders detected by NMR.Excision of Expanded GAA Repeats Alleviates the Molecular Phenotype of Friedreich's Ataxia.
P2860
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P2860
Rational selection of small molecules that increase transcription through the GAA repeats found in Friedreich's ataxia.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Rational selection of small mo ...... found in Friedreich's ataxia.
@ast
Rational selection of small mo ...... found in Friedreich's ataxia.
@en
type
label
Rational selection of small mo ...... found in Friedreich's ataxia.
@ast
Rational selection of small mo ...... found in Friedreich's ataxia.
@en
prefLabel
Rational selection of small mo ...... found in Friedreich's ataxia.
@ast
Rational selection of small mo ...... found in Friedreich's ataxia.
@en
P2093
P2860
P1433
P1476
Rational selection of small mo ...... s found in Friedreich's ataxia
@en
P2093
Hongzhi Xu
LaKechia Grant
Michael D Hebert
S H Subramony
P2860
P304
P356
10.1016/J.FEBSLET.2006.09.006
P407
P577
2006-09-15T00:00:00Z