Tau stabilizes microtubules by binding at the interface between tubulin heterodimers.
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NMR Meets Tau: Insights into Its Function and PathologyThe Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a CostMisframed ubiquitin and impaired protein quality control: an early event in Alzheimer's diseaseDirect force measurements reveal that protein Tau confers short-range attractions and isoform-dependent steric stabilization to microtubules.Stabilizer-Guided Inhibition of Protein-Protein InteractionsThe Dark Matter of BiologyConserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family MembersRabies Virus Infection Induces Microtubule Depolymerization to Facilitate Viral RNA Synthesis by Upregulating HDAC6.Human cyclophilin 40 unravels neurotoxic amyloids.Targeting intrinsically disordered proteins in rational drug discovery.Tau-ism: The Yin and Yang of Microtubule Sliding, Detachment, and Rupture.Recent Advances in the Study of Bipolar/Rod-Shaped Microglia and their Roles in Neurodegeneration.Tau secretion is correlated to an increase of Golgi dynamics.Tau Binds to Multiple Tubulin Dimers with Helical Structure.Knockdown of Tubulin Polymerization Promoting Protein Family Member 3 Suppresses Proliferation and Induces Apoptosis in Non-Small-Cell Lung Cancer.Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer's Disease: Comparison and Contrast with Microtubule-Associated Protein TauRole of tau in the spatial organization of axonal microtubules: keeping parallel microtubules evenly distributed despite macromolecular crowding.A conceptual view at microtubule plus end dynamics in neuronal axons.A functional role for intrinsic disorder in the tau-tubulin complex.Presence of a carboxy-terminal pseudorepeat and disease-like pseudohyperphosphorylation critically influence tau's interaction with microtubules in axon-like processes.The Elephant in the Room: The Role of Microtubules in Cancer.Stability properties of neuronal microtubules.Protein phosphatase 2A inhibition and subsequent cytoskeleton reorganization contributes to cell migration caused by microcystin-LR in human laryngeal epithelial cells (Hep-2).Monoaminergic neuropathology in Alzheimer's disease.The Role of the Carboxyl-Terminal Sequence of Tau and MAP2 in the Pathogenesis of DementiaSignaling pathways and posttranslational modifications of tau in Alzheimer's disease: the humanization of yeast cells.Cerebrospinal Fluid Biomarkers in Alzheimer's Disease-From Brain Starch to Bench and Bedside.The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells.Dysregulation of Microtubule Stability Impairs Morphofunctional Connectivity in Primary Neuronal Networks.Microtubules in health and degenerative disease of the nervous system.Oligomerization of the microtubule-associated protein tau is mediated by its N-terminal sequences: implications for normal and pathological tau action.Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effectsA validated antibody panel for the characterization of tau post-translational modifications.Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau.Probing the interaction of silver nanoparticles with tau protein and neuroblastoma cell line as nervous system models.Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry.Amyloidogenesis of Tau protein.Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ1-42 synaptotoxicity.Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase.Microtubule organization, dynamics and functions in differentiated cells.
P2860
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P2860
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers.
@ast
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers.
@en
type
label
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers.
@ast
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers.
@en
prefLabel
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers.
@ast
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers.
@en
P2093
P2860
P356
P1476
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers.
@en
P2093
Harindranath Kadavath
Henning Urlaub
Jacek Biernat
Katharina Tepper
Romina V Hofele
Satish Kumar
P2860
P304
P356
10.1073/PNAS.1504081112
P407
P577
2015-06-01T00:00:00Z