Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. - Wikidata - wikimedia - TriplyDB

Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention.

Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention.

http://www.wikidata.org/entity/Q35856946

about

The human protein disulfide isomerase gene family Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis Up- and down-regulation of adiponectin expression and multimerization: mechanisms and therapeutic implication Insulin stimulates interleukin-6 expression and release in LS14 human adipocytes through multiple signaling pathways The FGF21-adiponectin axis in controlling energy and vascular homeostasis Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk Adiponectin, driver or passenger on the road to insulin sensitivity?Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy-terminal tail Inside out: Bone marrow adipose tissue as a source of circulating adiponectin The non-canonical functions of the heme oxygenases The cell biology of fat expansion Novel adiponectin variants identified in type 2 diabetic patients reveal multimerization and secretion defects A highly conserved tryptophan in the N-terminal variable domain regulates disulfide bond formation and oligomeric assembly of adiponectin C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis Activation of AMPK by berberine promotes adiponectin multimerization in 3T3-L1 adipocytes NET37, a nuclear envelope transmembrane protein with glycosidase homology, is involved in myoblast differentiation Wild-type and missense mutants of retinoschisin co-assemble resulting in either intracellular retention or incorrect assembly of the functionally active octamer.Hypermetabolism, hyperphagia, and reduced adiposity in tankyrase-deficient mice.Ultrastructural localization of adiponectin protein in vasculature of normal and atherosclerotic mice.Disulfide-dependent self-assembly of adiponectin octadecamers from trimers and presence of stable octadecameric adiponectin lacking disulfide bonds in vitro.Fructose, Glucocorticoids and Adipose Tissue: Implications for the Metabolic Syndrome.A novel potential biomarker for metabolic syndrome in Chinese adults: Circulating protein disulfide isomerase family A, member 4.Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction Maternal overweight programs insulin and adiponectin signaling in the offspring.Role of redox environment on the oligomerization of higher molecular weight adiponectin.Adiponectin/adiponectin receptor in disease and aging.The multi-level action of fatty acids on adiponectin production by fat cells DsbA-L alleviates endoplasmic reticulum stress-induced adiponectin downregulation Endoplasmic reticulum (ER) localization is critical for DsbA-L protein to suppress ER stress and adiponectin down-regulation in adipocytes Expansion of Bone Marrow Adipose Tissue During Caloric Restriction Is Associated With Increased Circulating Glucocorticoids and Not With Hypoleptinemia.The role of adipose tissue in mediating the beneficial effects of dietary fish oil Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8 Substrate recognition by the protein disulfide isomerases.Expression of brain adiponectin in a murine model of transient cerebral ischemia.Adipokines as novel biomarkers and regulators of the metabolic syndrome.GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice Vascular biology of metabolic syndrome The inflammatory changes of adipose tissue in late pregnant mice.Dietary ω-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin.

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P2860

Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention.

http://www.wikidata.org/entity/Q35856946

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2007 nî lūn-bûn

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Molecular and Cellular Biology

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Ja-Young Kim

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Michael W Rajala

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Philipp E Scherer

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Tayeba Khan

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Todd D Schraw

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Zhao V Wang

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P2860

ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum

Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response

ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin

Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44

Secretion of immunoglobulin M assembly intermediates in the presence of reducing agents

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1-Lalpha

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10

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27

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Antonia Follenzi

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