Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.
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The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transportersPhysiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockoutsStructural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulationDomain-Swapping Switch Point in Ste20 Protein Kinase SPAKA trafficking-deficient mutant of KCC3 reveals dominant-negative effects on K-Cl cotransport functionRegulation of NKCC2 activity by inhibitory SPAK isoforms: KS-SPAK is a more potent inhibitor than SPAK2Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in miceStructural and biochemical insights into the activation mechanisms of germinal center kinase OSR1.Mechanism and synergism in epithelial fluid and electrolyte secretion.cAMP and Ca²⁺ signaling in secretory epithelia: crosstalk and synergism.A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.In silico analysis and experimental verification of OSR1 kinase - Peptide interaction.Short forms of Ste20-related proline/alanine-rich kinase (SPAK) in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage.cAMP-stimulated Cl- secretion is increased by glucocorticoids and inhibited by bumetanide in semicircular canal duct epithelium.STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy.Intracellular Cl- as a signaling ion that potently regulates Na+/HCO3- transporters.Exonic Re-Sequencing of the Chromosome 2q24.3 Parkinson's Disease LocusInhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke.Proteomic responses to elevated ocean temperature in ovaries of the ascidian Ciona intestinalis.Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target.Orai1 and STIM1 in ER/PM junctions: roles in pancreatic cell function and dysfunctionHypertension: the missing WNKs.Novel diuretic targetsRegulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.Physiology and pathophysiology of SLC12A1/2 transporters.WNK signalling pathways in blood pressure regulationExtrarenal roles of the with-no-lysine[K] kinases (WNKs).Association between Cullin-3 Single-Nucleotide Polymorphism rs17479770 and Essential Hypertension in the Male Chinese Han Population.Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus.Physiological role of SLC12 family members in the kidney.SPAK mediates KCC3-enhanced cervical cancer tumorigenesis.Regulation of Catalytic and Non-catalytic Functions of the Drosophila Ste20 Kinase Slik by Activation Segment PhosphorylationWNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter.Integrated compensatory network is activated in the absence of NCC phosphorylationPhosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4.DNPEP is not the only peptidase that produces SPAK fragments in kidney.Inactivation of SPAK kinase reduces body weight gain in mice fed a High-fat diet by improving energy expenditure and insulin sensitivity.Epstein-Barr Virus (EBV) Latent Protein EBNA3A Directly Targets and Silences the STK39 Gene in B Cells Infected by EBV.Down-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by the Kinases SPAK and OSR1.
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P2860
Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Molecular physiology of SPAK a ...... ases regulating ion transport.
@ast
Molecular physiology of SPAK a ...... ases regulating ion transport.
@en
type
label
Molecular physiology of SPAK a ...... ases regulating ion transport.
@ast
Molecular physiology of SPAK a ...... ases regulating ion transport.
@en
prefLabel
Molecular physiology of SPAK a ...... ases regulating ion transport.
@ast
Molecular physiology of SPAK a ...... ases regulating ion transport.
@en
P2860
P1476
Molecular physiology of SPAK a ...... ases regulating ion transport.
@en
P2093
Eric Delpire
Kenneth B Gagnon
P2860
P304
P356
10.1152/PHYSREV.00009.2012
P577
2012-10-01T00:00:00Z