Characterization of the Thermus thermophilus locus encoding peptide deformylase and methionyl-tRNA(fMet) formyltransferase.
about
An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathwayIdentification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanismsStructure of the Ni(II) complex of Escherichia coli peptide deformylase and suggestions on deformylase activities depending on different metal(II) centresStructure of crystalline Escherichia coli methionyl-tRNA(f)Met formyltransferase: comparison with glycinamide ribonucleotide formyltransferasePeptide deformylase in Staphylococcus aureus: resistance to inhibition is mediated by mutations in the formyltransferase geneBrucella abortus genes identified following constitutive growth and macrophage infectionHigh-throughput identification of inhibitors of human mitochondrial peptide deformylase.Solvent-assisted slow conversion of a dithiazole derivative produces a competitive inhibitor of peptide deformylase.Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents.Resistance of Streptococcus pneumoniae to deformylase inhibitors is due to mutations in defB.Expression of Escherichia coli methionyl-tRNA formyltransferase in Saccharomyces cerevisiae leads to formylation of the cytoplasmic initiator tRNA and possibly to initiation of protein synthesis with formylmethionine.Peptide deformylase: a target for novel antibiotics?Control of protein life-span by N-terminal methionine excisionMammalian mitochondrial methionyl-tRNA transformylase from bovine liver. Purification, characterization, and gene structure.Enzymatic properties of Escherichia coli peptide deformylase.Enantioselective hydrogenation of alpha-aminomethylacrylates containing a free NH group for the synthesis of beta-amino acid derivatives.Zinc is the metal cofactor of Borrelia burgdorferi peptide deformylase.Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation.Lysine 207 as the site of cross-linking between the 3'-end of Escherichia coli initiator tRNA and methionyl-tRNA formyltransferase.Delineation of alternative conformational states in Escherichia coli peptide deformylase via thermodynamic studies for the binding of actinonin.Mutations in three distinct loci cause resistance to peptide deformylase inhibitors in Bacillus subtilis.Potent sub-MIC effect of GSK1322322 and other peptide deformylase inhibitors on in vitro growth of Staphylococcus aureus.Three consecutive arginines are important for the mycobacterial peptide deformylase enzyme activityMapping the active site of the Haemophilus influenzae methionyl-tRNA formyltransferase: residues important for catalysis and tRNA binding.Proteome-wide analysis of the amino terminal status of Escherichia coli proteins at the steady-state and upon deformylation inhibition.Crystallization and preliminary X-ray crystallographic analysis of peptide deformylase (PDF) from Bacillus cereus in ligand-free and actinonin-bound forms.Peptide deformylase as an antibacterial drug target: assays for detection of its inhibition in Escherichia coli cell homogenates and intact cells.Peptide deformylase as an antibacterial drug target: target validation and resistance development.Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase.Truncation of peptide deformylase reduces the growth rate and stabilizes solvent production in Clostridium beijerinckii NCIMB 8052.Comparative analysis of the antibacterial activity of a novel peptide deformylase inhibitor, GSK1322322.The C-terminal residue of phage Vp16 PDF, the smallest peptide deformylase, acts as an offset element locking the active conformation.Aggregation of host endosomes by Salmonella requires SPI2 translocation of SseFG and involves SpvR and the fms-aroE intragenic region.Staphylococcus aureus formyl-methionyl transferase mutants demonstrate reduced virulence factor production and pathogenicityProteomic study of peptide deformylase inhibition in Streptococcus pneumoniae and Staphylococcus aureus.Structural and transcriptional comparative analysis of the S locus regions in two self-incompatible Brassica napus lines.On the role of conserved histidine 106 in 10-formyltetrahydrofolate dehydrogenase catalysis: connection between hydrolase and dehydrogenase mechanisms.
P2860
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P2860
Characterization of the Thermus thermophilus locus encoding peptide deformylase and methionyl-tRNA(fMet) formyltransferase.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Characterization of the Thermu ...... -tRNA(fMet) formyltransferase.
@ast
Characterization of the Thermu ...... -tRNA(fMet) formyltransferase.
@en
type
label
Characterization of the Thermu ...... -tRNA(fMet) formyltransferase.
@ast
Characterization of the Thermu ...... -tRNA(fMet) formyltransferase.
@en
prefLabel
Characterization of the Thermu ...... -tRNA(fMet) formyltransferase.
@ast
Characterization of the Thermu ...... -tRNA(fMet) formyltransferase.
@en
P2860
P1476
Characterization of the Thermu ...... -tRNA(fMet) formyltransferase.
@en
P2093
P2860
P304
P356
10.1128/JB.176.23.7387-7390.1994
P407
P577
1994-12-01T00:00:00Z