Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia.
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A Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of ChloroquineLeishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activitiesInteractions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparumStructural Basis for a Distinct Catalytic Mechanism in Trypanosoma brucei Tryparedoxin PeroxidaseStructural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I)Structure of Trypanosoma brucei glutathione synthetase: Domain and loop alterations in the catalytic cycle of a highly conserved enzymeDihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein CrystallographyThe bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blueBinding to large enzyme pockets: small-molecule inhibitors of trypanothione reductaseGold compounds as therapeutic agents for human diseasesThioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug targetDepletion of Plasmodium berghei plasmoredoxin reveals a non-essential role for life cycle progression of the malaria parasiteThe glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmissionInherited glutathione reductase deficiency and Plasmodium falciparum malaria--a case studyThioredoxin glutathione reductase as a novel drug target: evidence from Schistosoma japonicumMolecular mechanisms of drug resistance in natural Leishmania populations vary with genetic backgroundReal-time imaging of the intracellular glutathione redox potential in the malaria parasite Plasmodium falciparumTrypanothione reductase: a target protein for a combined in vitro and in silico screening approachGlutathionylation of trypanosomal thiol redox proteins.Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors.Reactions of antimalarial peroxides with each of leucomethylene blue and dihydroflavins: flavin reductase and the cofactor model exemplified.Essential multimeric enzymes in kinetoplastid parasites: A host of potentially druggable protein-protein interactions.Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.Caged glutathione - triggering protein interaction by light.Crystal structures from the Plasmodium peroxiredoxins: new insights into oligomerization and product binding.Manadoperoxides, a new class of potent antitrypanosomal agents of marine origin."Turn-on" fluorescence probe integrated polymer nanoparticles for sensing biological thiol moleculesEosin B as a novel antimalarial agent for drug-resistant Plasmodium falciparum.Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigens.Peroxiredoxins in parasites.Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents.Mitochondrial peroxidase TPx-2 is not essential in the blood and insect stages of Plasmodium berghei.Analyzing Thiol-Dependent Redox Networks in the Presence of Methylene Blue and Other Antimalarial Agents with RT-PCR-Supported in silico Modeling.Kinetoplastids: related protozoan pathogens, different diseases.The synthesis and inhibitory activity of dethiotrypanothione and analogues against trypanothione reductase1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agentsA physico-biochemical study on potential redox-cyclers as antimalarial and anti-schistosomal drugs.Glutathione-deficient Plasmodium berghei parasites exhibit growth delay and nuclear DNA damage.Trypanosoma cruzi antioxidant enzymes as virulence factors in Chagas disease.Glycobiology of the Leishmania parasite and emerging targets for antileishmanial drug discovery.
P2860
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P2860
Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Dithiol proteins as guardians ...... and malaria-causing plasmodia.
@ast
Dithiol proteins as guardians ...... and malaria-causing plasmodia.
@en
type
label
Dithiol proteins as guardians ...... and malaria-causing plasmodia.
@ast
Dithiol proteins as guardians ...... and malaria-causing plasmodia.
@en
prefLabel
Dithiol proteins as guardians ...... and malaria-causing plasmodia.
@ast
Dithiol proteins as guardians ...... and malaria-causing plasmodia.
@en
P2093
P2860
P356
P1476
Dithiol proteins as guardians ...... and malaria-causing plasmodia.
@en
P2093
Holger Bauer
R Heiner Schirmer
R Luise Krauth-Siegel
P2860
P304
P356
10.1002/ANIE.200300639
P407
P577
2005-01-01T00:00:00Z