A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice.
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Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugsImplications of GABAergic Neurotransmission in Alzheimer's DiseaseProteomic Substrate Identification for Membrane Proteases in the BrainNutritional and Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging and Alzheimer's Disease.Future Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors.Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice.BACE inhibition-dependent repair of Alzheimer's pathophysiology.Study of Exosomes Shed New Light on Physiology of Amyloidogenesis.Preclinical to phase II amyloid beta (Aβ) peptide modulators under investigation for Alzheimer's disease.Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends.APP mouse models for Alzheimer's disease preclinical studies.Modified Low-Dose Triiodo-L-thyronine Therapy Safely Improves Function Following Myocardial Ischemia-Reperfusion Injury.Widespread brain distribution and activity following i.c.v. infusion of anti-β-secretase (BACE1) in nonhuman primates.Tripchlorolide Attenuates β-amyloid Generation via Suppressing PPARγ-Regulated BACE1 Activity in N2a/APP695 Cells.BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology.Royal Jelly Reduces Cholesterol Levels, Ameliorates Aβ Pathology and Enhances Neuronal Metabolic Activities in a Rabbit Model of Alzheimer's Disease.β-Secretase BACE1 Promotes Surface Expression and Function of Kv3.4 at Hippocampal Mossy Fiber Synapses.Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes.Results of Beta Secretase-Inhibitor Clinical Trials Support Amyloid Precursor Protein-Independent Generation of Beta Amyloid in Sporadic Alzheimer's Disease.The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease
P2860
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P2860
A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
A novel BACE inhibitor NB-360 ...... mation in APP transgenic mice.
@ast
A novel BACE inhibitor NB-360 ...... mation in APP transgenic mice.
@en
type
label
A novel BACE inhibitor NB-360 ...... mation in APP transgenic mice.
@ast
A novel BACE inhibitor NB-360 ...... mation in APP transgenic mice.
@en
prefLabel
A novel BACE inhibitor NB-360 ...... mation in APP transgenic mice.
@ast
A novel BACE inhibitor NB-360 ...... mation in APP transgenic mice.
@en
P2093
P2860
P50
P1476
A novel BACE inhibitor NB-360 ...... mation in APP transgenic mice.
@en
P2093
Barbara Vogg
Heinrich Rueeger
Karen Beltz
Marina Tintelnot-Blomley
Peter Schmid
Rainer M Lueoend
Rainer Machauer
Siem Jacob Veenstra
Ulf Neumann
P2860
P2888
P356
10.1186/S13024-015-0033-8
P577
2015-09-03T00:00:00Z
P5875
P6179
1017293583