The multitubulin hypothesis revisited: what have we learned?
about
Vertebrates have conserved capping protein alpha isoforms with specific expression patternsSite-directed mutagenesis of alpha-tubulin. Reductive methylation studies of the Lys 394 regionAre tubulin isotypes functionally significantBeta tubulin isoforms are not interchangeable for rescuing impaired radial migration due to Tubb3 knockdownTubulin tyrosine ligase: protein and mRNA expression in developing rat skeletal muscleAn inherited TUBB2B mutation alters a kinesin-binding site and causes polymicrogyria, CFEOM and axon dysinnervation.Disease-associated mutations in TUBA1A result in a spectrum of defects in the tubulin folding and heterodimer assembly pathway.Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific beta-tubulin isotypeAntibodies to synthetic peptides from the tubulin regulatory domain interact with tubulin and microtubules.Specific alpha- and beta-tubulin isotypes optimize the functions of sensory Cilia in Caenorhabditis elegansHypothesis: microtubules, a key to Alzheimer diseaseDifferential turnover of tyrosinated and detyrosinated microtubulesAn oocyte-expressed alpha-tubulin gene in Xenopus laevis; sequences required for the initiation of transcription.Distinct alpha- and beta-tubulin isotypes are required for the positioning, differentiation and survival of neurons: new support for the 'multi-tubulin' hypothesis.Localization and immunogenicity of tubulin in the filarial nematodes Brugia malayi and B. pahangi.In vivo microtubules are copolymers of available beta-tubulin isotypes: localization of each of six vertebrate beta-tubulin isotypes using polyclonal antibodies elicited by synthetic peptide antigens.In vivo coassembly of a divergent beta-tubulin subunit (c beta 6) into microtubules of different functionDifferential utilization of beta-tubulin isotypes in differentiating neurites.Copolymerization of two distinct tubulin isotypes during microtubule assembly in vitroMicrotubule stabilization in pressure overload cardiac hypertrophy.Axonal transport of class II and III beta-tubulin: evidence that the slow component wave represents the movement of only a small fraction of the tubulin in mature motor axons.Regulation of tubulin levels and microtubule assembly in Saccharomyces cerevisiae: consequences of altered tubulin gene copy numberAutoregulated changes in stability of polyribosome-bound beta-tubulin mRNAs are specified by the first 13 translated nucleotides.Analysis of beta-tubulin sequences reveals highly conserved, coordinated amino acid substitutions. Evidence that these 'hot spots' are directly involved in the conformational change required for dynamic instability.Altered expression of M beta 2, the class II beta-tubulin isotype, in a murine J774.2 cell line with a high level of taxol resistance.Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.β-Tubulin mutations that cause severe neuropathies disrupt axonal transport.A survey of the alpha-tubulin gene family in chicken: unexpected sequence heterogeneity in the polypeptides encoded by five expressed genes.Truncation of the carboxy-terminal domain of yeast beta-tubulin causes temperature-sensitive growth and hypersensitivity to antimitotic drugs.The highly divergent beta-tubulins of Aspergillus nidulans are functionally interchangeable.The Expression of Tubb2b Undergoes a Developmental Transition in Murine Cortical Neurons.Molecular homology among members of the R gene family in maize.Differential interaction of synthetic peptides from the carboxyl-terminal regulatory domain of tubulin with microtubule-associated proteins.Isolation of alpha-tubulin genes from the human malaria parasite, Plasmodium falciparum: sequence analysis of alpha-tubulin.Identification of the tubulin gene family and sequence determination of one beta-tubulin gene in a cold-poikilotherm protozoan, the antarctic ciliate Euplotes focardii.The small genome of Arabidopsis contains at least nine expressed beta-tubulin genes.The predicted protein sequence of a fish testis-specific alpha-tubulin cDNA shows conservation of isotype-specific amino acid substitutions.Expression of unphosphorylated class III beta-tubulin isotype in neuroepithelial cells demonstrates neuroblast commitment and differentiation.Purification of assembly-competent tubulin from Saccharomyces cerevisiae.Development and maintenance of the neuronal cytoskeleton in aggregated cell cultures of fetal rat telencephalon and influence of elevated K+ concentrations.
P2860
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P2860
The multitubulin hypothesis revisited: what have we learned?
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
1987年论文
@zh
1987年论文
@zh-cn
name
The multitubulin hypothesis revisited: what have we learned?
@ast
The multitubulin hypothesis revisited: what have we learned?
@en
type
label
The multitubulin hypothesis revisited: what have we learned?
@ast
The multitubulin hypothesis revisited: what have we learned?
@en
prefLabel
The multitubulin hypothesis revisited: what have we learned?
@ast
The multitubulin hypothesis revisited: what have we learned?
@en
P2860
P921
P356
P1476
The multitubulin hypothesis revisited: what have we learned?
@en
P2093
D W Cleveland
P2860
P304
P356
10.1083/JCB.104.3.381
P407
P577
1987-03-01T00:00:00Z