Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing - Wikidata - wikimedia - TriplyDB

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

http://www.wikidata.org/entity/Q36305658

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The influence of the 5΄-terminal nucleotide on AgoshRNA activity and biogenesis: importance of the polymerase III transcription initiation site Minimal-length Synthetic shRNAs Formulated with Lipid Nanoparticles are Potent Inhibitors of Hepatitis C Virus IRES-linked Gene Expression in Mice Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing.Formulated minimal-length synthetic small hairpin RNAs are potent inhibitors of hepatitis C virus in mice with humanized livers.Towards Antiviral shRNAs Based on the AgoshRNA Design.Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys.Ribozyme-enhanced single-stranded Ago2-processed interfering RNA triggers efficient gene silencing with fewer off-target effects A new design of a lentiviral shRNA vector with inducible co-expression of ARGONAUTE 2 for enhancing gene silencing efficiency.Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy.Towards improved shRNA and miRNA reagents as inhibitors of HIV-1 replication.Development of Novel Small Hairpin RNAs That do not Require Processing by Dicer or AGO2.Toward optimization of AgoshRNA molecules that use a non-canonical RNAi pathway: variations in the top and bottom base pairs.An intracellular buildup reaction of active siRNA species from short RNA fragments.Dicer-independent processing of short hairpin RNAs.Improving miRNA Delivery by Optimizing miRNA Expression Cassettes in Diverse Virus Vectors.Influence of the loop size and nucleotide composition on AgoshRNA biogenesis and activity.Silencing of HIV-1 by AgoshRNA molecules.Deep Sequence Analysis of AgoshRNA Processing Reveals 3' A Addition and Trimming.Dicer-independent processing of small RNA duplexes: mechanistic insights and applications.Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA.Designing Ago2-specific siRNA/shRNA to Avoid Competition with Endogenous miRNAs.Probing the shRNA characteristics that hinder Dicer recognition and consequently allow Ago-mediated processing and AgoshRNA activity.Induction of RNAi Responses by Short Left-Handed Hairpin RNAi Triggers.Differences in silencing of mismatched targets by sliced versus diced siRNAs.

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P2860

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

http://www.wikidata.org/entity/Q36305658

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年学术文章

@wuu

2012年学术文章

@zh-cn

2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

2012年學術文章

@zh

2012年學術文章

@zh-hant

name

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

@ast

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

@en

type

label

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

@ast

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

@en

prefLabel

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

@ast

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

@en

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P1433

Nucleic Acids Research

P1476

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

@en

P2093

Anne Dallas

http://www.w3.org/2001/XMLSchema#string

Heini Ilves

http://www.w3.org/2001/XMLSchema#string

Joshua Shorenstein

http://www.w3.org/2001/XMLSchema#string

Pavan Kumar

http://www.w3.org/2001/XMLSchema#string

Qing Ge

http://www.w3.org/2001/XMLSchema#string

Sergei A Kazakov

http://www.w3.org/2001/XMLSchema#string

P2860

A human, ATP-independent, RISC assembly machine fueled by pre-miRNA

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

In vitro reconstitution of the human RISC-loading complex

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

ATP-dependent human RISC assembly pathways

Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity.

Cleavage of the siRNA passenger strand during RISC assembly in human cells

Architecture of ribosomal RNA: constraints on the sequence of "tetra-loops"

Structure of the guide-strand-containing argonaute silencing complex

Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex.

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9255-9271

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scholarly article

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10.1093/NAR/GKS662

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P407

P433

18

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40

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Michael McManus

Brian H Johnston

Trinna L Cuellar

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2012-07-18T00:00:00Z

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229322224

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22810205

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3467060

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