Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing
about
The influence of the 5΄-terminal nucleotide on AgoshRNA activity and biogenesis: importance of the polymerase III transcription initiation siteMinimal-length Synthetic shRNAs Formulated with Lipid Nanoparticles are Potent Inhibitors of Hepatitis C Virus IRES-linked Gene Expression in MicePreclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing.Formulated minimal-length synthetic small hairpin RNAs are potent inhibitors of hepatitis C virus in mice with humanized livers.Towards Antiviral shRNAs Based on the AgoshRNA Design.Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys.Ribozyme-enhanced single-stranded Ago2-processed interfering RNA triggers efficient gene silencing with fewer off-target effectsA new design of a lentiviral shRNA vector with inducible co-expression of ARGONAUTE 2 for enhancing gene silencing efficiency.Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variantsInhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy.Towards improved shRNA and miRNA reagents as inhibitors of HIV-1 replication.Development of Novel Small Hairpin RNAs That do not Require Processing by Dicer or AGO2.Toward optimization of AgoshRNA molecules that use a non-canonical RNAi pathway: variations in the top and bottom base pairs.An intracellular buildup reaction of active siRNA species from short RNA fragments.Dicer-independent processing of short hairpin RNAs.Improving miRNA Delivery by Optimizing miRNA Expression Cassettes in Diverse Virus Vectors.Influence of the loop size and nucleotide composition on AgoshRNA biogenesis and activity.Silencing of HIV-1 by AgoshRNA molecules.Deep Sequence Analysis of AgoshRNA Processing Reveals 3' A Addition and Trimming.Dicer-independent processing of small RNA duplexes: mechanistic insights and applications.Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA.Designing Ago2-specific siRNA/shRNA to Avoid Competition with Endogenous miRNAs.Probing the shRNA characteristics that hinder Dicer recognition and consequently allow Ago-mediated processing and AgoshRNA activity.Induction of RNAi Responses by Short Left-Handed Hairpin RNAi Triggers.Differences in silencing of mismatched targets by sliced versus diced siRNAs.
P2860
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P2860
Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年學術文章
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2012年學術文章
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2012年學術文章
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name
Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing
@ast
Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing
@en
type
label
Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing
@ast
Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing
@en
prefLabel
Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing
@ast
Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing
@en
P2093
P2860
P50
P356
P1476
Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing
@en
P2093
Anne Dallas
Heini Ilves
Joshua Shorenstein
Pavan Kumar
Sergei A Kazakov
P2860
P304
P356
10.1093/NAR/GKS662
P407
P577
2012-07-18T00:00:00Z