Amino acid sequence diversity within the family of antibodies bearing the major antiarsonate cross-reactive idiotype of the A strain mouse.
about
Identification of mutant monoclonal antibodies with increased antigen bindingStructural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-foldOrganization of the murine immunoglobulin VH complex in the inbred strains.Identity of the V kappa 10-Ars-A gene segments of the A/J and BALB/c strains.Somatic diversification of S107 from an antiphosphocholine to an anti-DNA autoantibody is due to a single base change in its heavy chain variable region.Somatic evolution of variable region structures during an immune response.Site-directed mutagenesis of an invariant amino acid residue at the variable-diversity segments junction of an antibodyDifferent epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response.Clonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutationComplete amino acid sequence of heavy chain variable regions derived from two monoclonal anti-p-azophenylarsonate antibodies of BALB/c mice expressing the major cross-reactive idiotype of the A/J strainIdiotype connectance in the immune system. II. A heavy chain variable region idiotope that dominates the antibody response to the p-azobenzenearsonate group is a minor idiotope in the response to trinitrophenyl group.Heavy chain variable region. Multiple gene segments encode anti-4-(hydroxy-3-nitro-phenyl)acetyl idiotypic antibodies.Parallel evolution of antibody variable regions by somatic processes: consecutive shared somatic alterations in VH genes expressed by independently generated hybridomas apparently acquired by point mutation and selection rather than by gene conversiSingle germline VH and V kappa genes encode predominating antibody variable regions elicited in strain A mice by immunization with p-azophenylarsonate.Structural characterization of antiidiotypic antibodies. Evidence that Ab2s are derived from the germline differently than Ab1sComplete amino acid sequences of variable regions of two human IgM rheumatoid factors, BOR and KAS of the Wa idiotypic family, reveal restricted use of heavy and light chain variable and joining region gene segmentsMolecular analysis of antigen recognition by insulin-specific T-cell hybridomas from B6 wild-type and bm12 mutant mice.Oligonucleotide-directed mutagenesis of antibody combining sites.Studies on the somatic instability of immunoglobulin genes in vivo and in cultured cells.Polyclonal antibody catalytic variability.
P2860
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P2860
Amino acid sequence diversity within the family of antibodies bearing the major antiarsonate cross-reactive idiotype of the A strain mouse.
description
1983 nî lūn-bûn
@nan
1983年の論文
@ja
1983年学术文章
@wuu
1983年学术文章
@zh-cn
1983年学术文章
@zh-hans
1983年学术文章
@zh-my
1983年学术文章
@zh-sg
1983年學術文章
@yue
1983年學術文章
@zh
1983年學術文章
@zh-hant
name
Amino acid sequence diversity ...... diotype of the A strain mouse.
@ast
Amino acid sequence diversity ...... diotype of the A strain mouse.
@en
type
label
Amino acid sequence diversity ...... diotype of the A strain mouse.
@ast
Amino acid sequence diversity ...... diotype of the A strain mouse.
@en
prefLabel
Amino acid sequence diversity ...... diotype of the A strain mouse.
@ast
Amino acid sequence diversity ...... diotype of the A strain mouse.
@en
P2860
P356
P1476
Amino acid sequence diversity ...... diotype of the A strain mouse.
@en
P2093
C A Slaughter
P2860
P304
P356
10.1084/JEM.158.5.1615
P407
P577
1983-11-01T00:00:00Z