Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease
about
Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect.The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II moleculesCompetition between two MHC binding registers in a single peptide processed from myelin basic protein influences tolerance and susceptibility to autoimmunity.PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice.HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease ProgressionBIITE: A Tool to Determine HLA Class II Epitopes from T Cell ELISpot DataMHC multimerization, antigen expression and the induction of APC amnesia in the developing immune response.The role of lysosomal proteinases in MHC class II-mediated antigen processing and presentation.Properties of HLA class II molecules divergently associated with Goodpasture's disease.Interaction of Brucella abortus lipopolysaccharide with major histocompatibility complex class II molecules in B lymphocytes.Lessons from BXSB and related mouse models.Longevity of SLE-prone mice increased by dietary 2-mercaptoethanol via a mechanism imprinted within the first 28 days of life.Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competitionEffect of MHC class I diversification on influenza epitope-specific CD8+ T cell precursor frequency and subsequent effector function.Cell-surface MHC density profiling reveals instability of autoimmunity-associated HLA.The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic modelUnresponsiveness to a self-peptide of mouse lysozyme owing to hindrance of T cell receptor-major histocompatibility complex/peptide interaction caused by flanking epitopic residuesDM determines the cryptic and immunodominant fate of T cell epitopes.A peptide-binding motif for I-A(g7), the class II major histocompatibility complex (MHC) molecule of NOD and Biozzi AB/H miceMajor histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities.Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T cell responseSimilar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes.Collagen Specific T-Cell Repertoire and HLA-DR Alleles: Biomarkers of Active Refractory Rheumatoid ArthritisTransgenically induced GAD tolerance curtails the development of early beta-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other beta-cell antigens.MHC Class II Polymorphisms, Autoreactive T-Cells, and Autoimmunity.Associations of human leukocyte antigens with autoimmune diseases: challenges in identifying the mechanism.Tolerance induction as a therapeutic strategy for the control of autoimmune endocrine disease in mouse models.Cathepsin S and an asparagine-specific endoprotease dominate the proteolytic processing of human myelin basic protein in vitro.Endocytic recycling is required for the presentation of an exogenous peptide via MHC class II molecules.Characterization of the interaction of a TCR alpha chain variable domain with MHC II I-A molecules.Processing and presentation of endocytically acquired protein antigens by MHC class II and class I molecules.Determinant flanking regions and the design of appropriate vaccines.Immunogenicity of calreticulin-bound murine leukemia virus glycoprotein gp90.Allocation of helper T-cell epitope immunodominance according to three-dimensional structure in the human immunodeficiency virus type I envelope glycoprotein gp120.Major histocompatibility complex class II-dependent unfolding, transport, and degradation of endogenous proteins.Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus.Amino acid residue substitution at T-cell determinant-flanking sites in beta-lactoglobulin modulates antigen presentation to T cells through subtle conformational change.Both central and peripheral tolerance mechanisms play roles in diabetes prevention in NOD-E transgenic mice.Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine.Effect of X- and Y-Box Deletions on the Development of Diabetes in H-2Ealpha-Chain Transgenic Nonobese Diabetic Mice
P2860
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P2860
Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
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1993年學術文章
@zh-hant
name
Determinant capture as a possi ...... olecules in autoimmune disease
@ast
Determinant capture as a possi ...... olecules in autoimmune disease
@en
type
label
Determinant capture as a possi ...... olecules in autoimmune disease
@ast
Determinant capture as a possi ...... olecules in autoimmune disease
@en
prefLabel
Determinant capture as a possi ...... olecules in autoimmune disease
@ast
Determinant capture as a possi ...... olecules in autoimmune disease
@en
P2093
P2860
P356
P1476
Determinant capture as a possi ...... olecules in autoimmune disease
@en
P2093
M Clare-Salzler
S Trembleau
P2860
P304
P356
10.1084/JEM.178.5.1675
P407
P577
1993-11-01T00:00:00Z