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Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.RasRas protein/cAMP-dependent protein kinase signaling is negatively regulated by a deubiquitinating enzyme, Ubp3, in yeast.Ras-induced cellular events (review)Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytesPlatelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell typesRapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblastsSolution structure of GAP SH3 domain by 1H NMR and spatial arrangement of essential Ras signaling-involved sequence.Isolation of multiple mouse cDNAs with coding homology to Saccharomyces cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24.Phospholipase A/Acyltransferase enzyme activity of H-rev107 inhibits the H-RAS signaling pathwayPolarity proteins and cell-cell interactions in the testis.Triepitopic antibody fusions inhibit cetuximab-resistant BRAF and KRAS mutant tumors via EGFR signal repression.Growth factor signaling pathways in vascular development.Cyclic AMP selectively enhances bradykinin receptor synthesis and expression in cultured arterial smooth muscle. Inhibition of angiotensin II and vasopressin response.Complex formation between RAS and RAF and other protein kinasesMos induces the in vitro activation of mitogen-activated protein kinases in lysates of frog oocytes and mammalian somatic cellsAstrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.Farnesyltransferase inhibitors: mechanism and applications.A single residue can modify target-binding affinity and activity of the functional domain of the Rho-subfamily GDP dissociation inhibitors.A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogasterEstablishment of genetically diverse patient-derived xenografts of colorectal cancer.Neurofibromin in the brain.Recent advances in the management of carcinoma of the rectumNeurocognitive dysfunction in children with neurofibromatosis type 1.The ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels.Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinaseSpecific K-ras2 mutations in human sporadic colorectal adenomas are associated with DNA near-diploid aneuploidy and inhibition of proliferation.Novel targeted agents in the treatment of lung cancer.A splicing enhancer in the 3'-terminal c-H-ras exon influences mRNA abundance and transforming activityEvidence that beta3 integrin-induced Rac activation involves the calpain-dependent formation of integrin clusters that are distinct from the focal complexes and focal adhesions that form as Rac and RhoA become activeNegative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth.Residues crucial for Ras interaction with GDP-GTP exchangers.Phosphoinositide 3-kinase-dependent membrane recruitment of p62(dok) is essential for its negative effect on mitogen-activated protein (MAP) kinase activation.Suppression of oncogenic Ras by mutant neurofibromatosis type 1 genes with single amino acid substitutionsA mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cellsState of the art chemotherapeutic management of pediatric brain tumors.GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.Molecular cloning and characterization of rho, a ras-related small GTP-binding protein from the garden pea.Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activityIdentification of a ras-activated enhancer in the mouse osteopontin promoter and its interaction with a putative ETS-related transcription factor whose activity correlates with the metastatic potential of the cell.ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma.
P2860
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P2860
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
@zh-cn
1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
@yue
1991年學術文章
@zh
1991年學術文章
@zh-hant
name
Regulators and effectors of ras proteins.
@ast
Regulators and effectors of ras proteins.
@en
type
label
Regulators and effectors of ras proteins.
@ast
Regulators and effectors of ras proteins.
@en
prefLabel
Regulators and effectors of ras proteins.
@ast
Regulators and effectors of ras proteins.
@en
P1476
Regulators and effectors of ras proteins.
@en
P2093
P304
P356
10.1146/ANNUREV.CB.07.110191.003125
P577
1991-01-01T00:00:00Z