The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4.
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Down-regulation of CTLA-4 by HIV-1 Nef proteinHuman immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tailProline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activityHuman immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytesRefined solution structure and backbone dynamics of HIV-1 Nef.Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.gag, vif, and nef genes contribute to the homologous viral interference induced by a nonproducer human immunodeficiency virus type 1 (HIV-1) variant: identification of novel HIV-1-inhibiting viral protein mutants.Rabbit cells expressing human CD4 and human CCR5 are highly permissive for human immunodeficiency virus type 1 infectionHuman immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabetaReconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef/p21-activated kinase 2 complex.CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.Comparing the ex vivo fitness of CCR5-tropic human immunodeficiency virus type 1 isolates of subtypes B and C.Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines.Detection of CD4+ T cells harboring human immunodeficiency virus type 1 DNA by flow cytometry using simultaneous immunophenotyping and PCR-driven in situ hybridization: evidence of epitope masking of the CD4 cell surface molecule in vivoInhibition of Nef- and phorbol ester-induced CD4 degradation by macrolide antibiotics.Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral proteaseMechanism of human immunodeficiency virus type 1 localization in CD4-negative thymocytes: differentiation from a CD4-positive precursor allows productive infection.Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8+ T Cell Killing.The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3'-long terminal repeat transgeneHIV-induced apoptosis requires the CD4 receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck.HIV-1 Nef increases T cell activation in a stimulus-dependent manner.Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.Molecular biology of the human immunodeficiency virus accessory proteinsAnalysis of human immunodeficiency virus type 1 nef gene sequences present in vivo.Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells.Human immunodeficiency virus type 1 Vpu protein induces degradation of chimeric envelope glycoproteins bearing the cytoplasmic and anchor domains of CD4: role of the cytoplasmic domain in Vpu-induced degradation in the endoplasmic reticulum.Costimulation of T-cell activation and virus production by B7 antigen on activated CD4+ T cells from human immunodeficiency virus type 1-infected donorsNef can enhance the infectivity of receptor-pseudotyped human immunodeficiency virus type 1 particles.HIV-1 Nef and T-cell activation: a history of contradictions.Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain.Molecular biology and pathogenesis of animal lentivirus infections.Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry.The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef.Human immunodeficiency virus type 1 Nef protein down-regulates transcription factors NF-kappa B and AP-1 in human T cells in vitro after T-cell receptor stimulation.Biological, molecular, and structural analysis of a cytopathic variant from a molecularly cloned simian immunodeficiency virus.Context-dependent role of human immunodeficiency virus type 1 auxiliary genes in the establishment of chronic virus producers.Tetraspanins, Another Piece in the HIV-1 Replication Puzzle
P2860
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P2860
The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
The negative effect of human i ...... the cytoplasmic domain of CD4.
@ast
The negative effect of human i ...... the cytoplasmic domain of CD4.
@en
type
label
The negative effect of human i ...... the cytoplasmic domain of CD4.
@ast
The negative effect of human i ...... the cytoplasmic domain of CD4.
@en
prefLabel
The negative effect of human i ...... the cytoplasmic domain of CD4.
@ast
The negative effect of human i ...... the cytoplasmic domain of CD4.
@en
P2093
P2860
P1433
P1476
The negative effect of human i ...... the cytoplasmic domain of CD4.
@en
P2093
P2860
P304
P407
P577
1993-03-01T00:00:00Z