The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma cells and pulmonary/cardiovascular vessels.
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Conformational Variations of Both Phosphodiesterase-5 and Inhibitors Provide the Structural Basis for the Physiological Effects of Vardenafil and SildenafilAn insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studiesGRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human diseaseThe phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporterType 5 phosphodiesterase expression is a critical determinant of the endothelial cell angiogenic phenotype.Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase GcGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.Regulation of OSU-03012 toxicity by ER stress proteins and ER stress-inducing drugs.Acute effect of phosphodiesterase type 5 inhibitor on serum oxidative status and prolidase activities in men with erectile dysfunction.PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporterSildenafil inhibits the growth of human colorectal cancer in vitro and in vivoOSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer TherapiesGRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases.Repurposing phosphodiesterase-5 inhibitors as chemoadjuvants.Pharmacotherapy of acute lung injury and acute respiratory distress syndromePharmacological modulation of cytotoxicity and cellular uptake of anti-cancer drugs by PDE5 inhibitors in lung cancer cellsThe role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatmentThe multiple and enigmatic roles of guanylyl cyclase C in intestinal homeostasis.Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1.Synthesis of novel tadalafil analogues and their evaluation as phosphodiesterase inhibitors and anticancer agents.Expression and therapeutic targeting of dopamine receptor-1 (D1R) in breast cancer.Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling.Assessment of the acute effects of tadalafil on the cardiovascular system based on examination of serum oxidative status and paraoxonase activity in men with erectile dysfunction: a preliminary study.Potential synergistic effect of phosphodiesterase inhibitors with chemotherapy in lung cancer.Phosphodiesterase type 5 and cancers: progress and challenges.Sildenafil citrate improves the delivery and anticancer activity of doxorubicin formulations in a mouse model of breast cancer.Modulation of thioacetamide-induced liver fibrosis/cirrhosis by sildenafil treatment.Repurposing drugs in oncology (ReDO)-selective PDE5 inhibitors as anti-cancer agents.
P2860
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P2860
The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma cells and pulmonary/cardiovascular vessels.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The novel functions of cGMP-sp ...... monary/cardiovascular vessels.
@ast
The novel functions of cGMP-sp ...... monary/cardiovascular vessels.
@en
type
label
The novel functions of cGMP-sp ...... monary/cardiovascular vessels.
@ast
The novel functions of cGMP-sp ...... monary/cardiovascular vessels.
@en
prefLabel
The novel functions of cGMP-sp ...... monary/cardiovascular vessels.
@ast
The novel functions of cGMP-sp ...... monary/cardiovascular vessels.
@en
P1476
The novel functions of cGMP-sp ...... monary/cardiovascular vessels.
@en
P2093
Samuel J Strada
P304
P356
10.2174/156802607779941198
P577
2007-01-01T00:00:00Z