Substrate specificity of gamma-secretase and other intramembrane proteases.
about
Ferritin light chain interacts with PEN-2 and affects γ-secretase activityGamma-secretase activating protein is a therapeutic target for Alzheimer's diseaseHuman CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complexNotch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cellsAmyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta poresToward the structure of presenilin/γ-secretase and presenilin homologsComplex regulation of γ-secretase: from obligatory to modulatory subunitsIdentification of an archaeal presenilin-like intramembrane proteaseAph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substratesPresenilin/gamma-secretase cleaves CD46 in response to Neisseria infectionAftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease-related pathogenesisInhibition of Notch activity promotes nonmitotic regeneration of hair cells in the adult mouse utriclesAlzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.Gene expression profiling in cells with enhanced gamma-secretase activity.gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranesNOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma.Presenilin controls CBP levels in the adult Drosophila central nervous system.Prognostic roles of Notch receptor mRNA expression in human ovarian cancer.An overview of APP processing enzymes and products.Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrenceThe cell giveth and the cell taketh away: an overview of Notch pathway activation by endocytic trafficking of ligands and receptorsPapillomavirus infection requires gamma secretase.Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's diseaseSecretion stimulates intramembrane proteolysis of a secretory granule membrane enzymeSubmersion and hypoxia inhibit ciliated cell differentiation in a notch-dependent mannerRBPJ is a novel target for rhabdomyosarcoma therapy.Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells.Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteasesSecretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways.Evidence from solid-state NMR for nonhelical conformations in the transmembrane domain of the amyloid precursor protein.Role of Notch and its oncogenic signaling crosstalk in breast cancer.Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinomaLoss of presenilin 2 is associated with increased iPLA2 activity and lung tumor development.Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complexDrug development for Alzheimer's disease: recent progressLysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane reInvestigational Notch and Hedgehog inhibitors--therapies for cardiovascular disease.Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.
P2860
Q24293193-0C0B44C1-4E27-4398-A4D7-77286240BED6Q24298408-B793A30B-2AB0-4266-923E-1CEFCBCA4418Q24303928-5984D08E-E85B-4920-97A2-DA264C36E347Q24329090-55935ABF-4B4B-48DB-A73C-2776E181D9A8Q26738355-5CF6A211-BC50-48CF-AB39-29D57A2EA15CQ27002018-315446C2-30C6-41A2-BEF4-618A5D2276B1Q28080576-A65F5CE9-CEAD-407A-8D94-D7E85F4A47B8Q28475644-4E19A9B9-1DEE-42D2-B6DB-81405459E3D9Q28570929-76B800BE-BC89-4C18-9388-49B7F4DBF9EAQ28817811-47CAB337-71BD-43C3-A98D-77453C4D4885Q28828789-2C6E3BFB-77BC-4C5E-A342-D6848635E43EQ28833244-698611E1-C1F8-4F10-A991-737524E864DDQ30468270-12E0AF83-E2C1-4382-80E1-AD18534B130CQ31057900-AC1221A7-E62A-448A-AFE7-A7FE4906CB0DQ33504576-C4E89914-4BC8-475B-A7E0-ADA5CB363BBEQ33545253-0E745F27-2B04-430C-B98F-92848C694B19Q33622402-43350786-3A49-4675-882D-F142EAA60E57Q33778517-D9D35EEC-44CC-4971-914F-40D7A4FF6055Q33779227-8B60E830-D48B-462A-BD06-AF2A5FF6E6B0Q33927819-BE927687-2D02-4470-9E8F-4F8288066FC6Q34093329-BE952E67-58ED-421C-BB8E-A8D473776A53Q34101839-C196BBC8-B01E-4984-ADB4-EE61C547B240Q34126479-D368DFE2-B09C-4E04-BB9E-1CD6DE546686Q34178325-4CB967C5-98CD-4070-8F1F-4F41089C3D1FQ34221138-0F5332E2-FA59-43D4-877B-266238C8C7D0Q34251212-2DAEBA01-EEB4-4147-93E1-DE3E767E8DDAQ34305508-EC87E981-2169-4E15-8618-551366DC6408Q34335672-B060CC4B-ACD7-4624-A0C7-985D5A3B05ACQ34355472-6C9EB7F6-847F-4F03-BB30-CD2A91F79E54Q34382868-609551EC-3924-474D-8806-DDB1499A4EDDQ34469573-7DDEDCA4-A4C4-4175-AB56-56A8B63E23F5Q34535890-49F27B81-DED9-4B4A-9AAB-5E48191557BAQ34697373-7523C7EA-B979-43FB-AEB3-6F5484DF6BB4Q34786512-7A84082D-E13D-43E5-8BA7-ABC892D89BB5Q34876944-C040AF6A-3245-4221-8902-B50CC2B66E17Q35172682-1039FA2E-9F11-4726-9ADB-36840839FAC7Q35545974-99F06F28-2CB7-4085-97FB-05C4A5F9FBAFQ35562694-DD2CBEE4-FB4A-4371-85FA-E1067197B195Q35603713-910AD889-DFC4-40DA-BA72-ACF8D5208F79Q35658184-1645CD70-58D7-4D3C-9034-C64C65EE536E
P2860
Substrate specificity of gamma-secretase and other intramembrane proteases.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Substrate specificity of gamma-secretase and other intramembrane proteases.
@en
Substrate specificity of gamma-secretase and other intramembrane proteases.
@nl
type
label
Substrate specificity of gamma-secretase and other intramembrane proteases.
@en
Substrate specificity of gamma-secretase and other intramembrane proteases.
@nl
prefLabel
Substrate specificity of gamma-secretase and other intramembrane proteases.
@en
Substrate specificity of gamma-secretase and other intramembrane proteases.
@nl
P2860
P1476
Substrate specificity of gamma-secretase and other intramembrane proteases.
@en
P2093
P2860
P2888
P304
P356
10.1007/S00018-008-7462-2
P577
2008-05-01T00:00:00Z