Intriguing nucleic-acid-binding features of mammalian prion protein.
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RepA-WH1, the agent of an amyloid proteinopathy in bacteria, builds oligomeric pores through lipid vesicles.Kosmotropic anions promote conversion of recombinant prion protein into a PrPSc-like misfolded formMisfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer.Globular domain of the prion protein needs to be unlocked by domain swapping to support prion protein conversionLigand binding and hydration in protein misfolding: insights from studies of prion and p53 tumor suppressor proteins.Probing the conformation of a prion protein fibril with hydrogen exchange.Synthetic scrapie infectivity: interaction between recombinant PrP and scrapie brain-derived RNA.Sequestration of cellular interacting partners by protein aggregates: implication in a loss-of-function pathology.Involvement of endogenous retroviruses in prion diseases.Inhibition of TDP-43 aggregation by nucleic acid bindingProtein folding activity of the ribosome (PFAR) -- a target for antiprion compoundsBinding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid.Proteomic consequences of expression and pathological conversion of the prion protein in inducible neuroblastoma N2a cells.Pre-amyloid oligomers of the proteotoxic RepA-WH1 prionoid assemble at the bacterial nucleoidDisease-specific motifs can be identified in circulating nucleic acids from live elk and cattle infected with transmissible spongiform encephalopathies.Prion protein-coated magnetic beads: synthesis, characterization and development of a new ligands screening method.The peculiar interaction between mammalian prion protein and RNAThe various facets of the protein-folding activity of the ribosome.Allosteric function and dysfunction of the prion protein.The role of RNA in mammalian prion protein conversion.Role of proteomics in understanding prion infection.The aggregation of mutant p53 produces prion-like properties in cancer.RepA-WH1 prionoid: a synthetic amyloid proteinopathy in a minimalist hostAnalysis of nucleic acid chaperoning by the prion protein and its inhibition by oligonucleotides.The "Jekyll and Hyde" Actions of Nucleic Acids on the Prion-like Aggregation of Proteins.Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease?Prion-like proteins and their computational identification in proteomes.Pathological implications of nucleic acid interactions with proteins associated with neurodegenerative diseasesConditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides.Prion protein complexed to N2a cellular RNAs through its N-terminal domain forms aggregates and is toxic to murine neuroblastoma cellsM1 RNA is important for the in-cell solubility of its cognate C5 protein: Implications for RNA-mediated protein folding.Prion protein amyloid formation under native-like conditions involves refolding of the C-terminal alpha-helical domain.Direct assessment in bacteria of prionoid propagation and phenotype selection by Hsp70 chaperone.Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway.Binding of recombinant but not endogenous prion protein to DNA causes DNA internalization and expression in mammalian cells.Biophysical and morphological studies on the dual interaction of non-octarepeat prion protein peptides with copper and nucleic acids.Exploring the essential collective dynamics of interacting proteins: application to prion protein dimers.Trapping the monomer of a non-amyloidogenic variant of transthyretin: exploring its possible use as a therapeutic strategy against transthyretin amyloidogenic diseases.Distinct modulatory role of RNA in the aggregation of the tumor suppressor protein p53 core domain.Nucleation of Amyloid Oligomers by RepA-WH1-Prionoid-Functionalized Gold Nanorods.
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P2860
Intriguing nucleic-acid-binding features of mammalian prion protein.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 19 February 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Intriguing nucleic-acid-binding features of mammalian prion protein.
@en
Intriguing nucleic-acid-binding features of mammalian prion protein.
@nl
type
label
Intriguing nucleic-acid-binding features of mammalian prion protein.
@en
Intriguing nucleic-acid-binding features of mammalian prion protein.
@nl
prefLabel
Intriguing nucleic-acid-binding features of mammalian prion protein.
@en
Intriguing nucleic-acid-binding features of mammalian prion protein.
@nl
P50
P1476
Intriguing nucleic-acid-binding features of mammalian prion protein.
@en
P2093
Luís Maurício T R Lima
P304
P356
10.1016/J.TIBS.2007.11.003
P577
2008-02-19T00:00:00Z