Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease - Wikidata - wikimedia - TriplyDB

Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease

Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease

http://www.wikidata.org/entity/Q37128372

about

Strategies for treatment in Alexander disease Alexander disease Dysfunctions of neuronal and glial intermediate filaments in disease Post-translational modifications of intermediate filament proteins: mechanisms and functions Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin GFAP isoforms control intermediate filament network dynamics, cell morphology, and focal adhesions.The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease Comparison of the gene expression profiles of human fetal cortical astrocytes with pluripotent stem cell derived neural stem cells identifies human astrocyte markers and signaling pathways and transcription factors active in human astrocytes Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell viability.Astrocyte Dysfunction in Developmental Neurometabolic Diseases.Protein misfolding and oxidative stress promote glial-mediated neurodegeneration in an Alexander disease model Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease.Neurological diseases as primary gliopathies: a reassessment of neurocentrism Effects of maternal immune activation on gene expression patterns in the fetal brain Beneficial effects of Nrf2 overexpression in a mouse model of Alexander disease.Study of αB-crystallin expression in Gerbil BCAO model of transient global cerebral ischemia.Nitric oxide mediates glial-induced neurodegeneration in Alexander disease An In Vivo Pharmacological Screen Identifies Cholinergic Signaling as a Therapeutic Target in Glial-Based Nervous System Disease.Alzheimer disease periventricular white matter lesions exhibit specific proteomic profile alterations Protein changes in immunodepleted cerebrospinal fluid from a transgenic mouse model of Alexander disease detected using mass spectrometry GFAP expression as an indicator of disease severity in mouse models of Alexander disease.Promotion of axon regeneration and inhibition of astrocyte activation by alpha A-crystallin on crushed optic nerve.αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls.Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease Small heat shock proteins mediate cell-autonomous and -nonautonomous protection in a Drosophila model for environmental-stress-induced degeneration.Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation.The protective and therapeutic function of small heat shock proteins in neurological diseases.Myelination: do astrocytes play a role?Emerging role of autophagy in pediatric neurodegenerative and neurometabolic diseases.ASTROCYTES: EMERGING STARS IN LEUKODYSTROPHY PATHOGENESIS.Regulation of αA- and αB-crystallins via phosphorylation in cellular homeostasis.Lessons from Animal Models of Cytoplasmic Intermediate Filament Proteins.Leukodystrophies: a proposed classification system based on pathological changes and pathogenetic mechanisms.Traumatically injured astrocytes release a proteomic signature modulated by STAT3-dependent cell survival.Chaperones: needed for both the good times and the bad times.Alexander Disease Mutations Produce Cells with Coexpression of Glial Fibrillary Acidic Protein and NG2 in Neurosphere Cultures and Inhibit Differentiation into Mature Oligodendrocytes Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-γ and alpha B-crystallin.Effects of a polymorphism in the GFAP promoter on the age of onset and ambulatory disability in late-onset Alexander disease.

P2860

Q24596794-F4E10956-0490-4B29-88C0-D7E107FC07D1 Q24633313-9AADE578-42DB-425B-B41E-89F7D129E076 Q24657653-C70924F2-BC08-4D51-9E03-64428E7AE5D7 Q27004670-3F05EE18-BA68-43EF-BA05-6E67C6EE5D92 Q28239546-168891CD-00C8-47C6-A7AA-247ABFF25EB3 Q28510018-4D4FAF6B-C5F2-469F-9DA4-488E8367A3B6 Q30816841-4BD31097-4B9C-42D0-AA92-58E2061D08B8 Q30843456-9357FE8C-BC03-40AF-AF17-1D2DCF3B3EEB Q31161502-43D44A92-7FD4-466D-B76A-5AA2EC8E4ABF Q34200416-1FF0AB12-BF9E-4E83-94D3-68BC63FA6115 Q34679071-1713B3E1-F0B9-4B09-9D59-E8316D3EC415 Q34857360-78CF0985-EBAC-4391-B91F-47D0A0BB96E6 Q35778386-D9D61CC9-6EC6-4EC5-AD75-3FA9F677519A Q35872654-D8A695EB-1779-4235-BC6B-6481A27D87C8 Q35913929-91042EF1-B5CB-4598-92E1-0D3D21383E54 Q36251679-AD2C579F-3068-477B-BF3C-272F695F988C Q36336732-DCB760B9-AF05-4E4C-9098-E5CFE24B989C Q36360991-28734452-DCB8-4992-980B-3F5E97BEE8A5 Q36534299-884B32F2-8455-4039-9E91-264E85E38C50 Q36597843-800E41C7-5872-4BE4-9C4B-0F9B431EDC3A Q36599253-789D64DB-C36A-4ED6-9C1F-31418C144BCA Q36706156-007674D8-41C9-41B1-BB86-35E606151CD4 Q37110854-DEC128A1-8BF1-43B2-B03F-20D26E7A7E1E Q37178561-FE3FBE10-5D87-43CD-ABDA-D14887F84275 Q37235572-25AF72B1-23D8-4CCD-82F8-562C26347358 Q37284065-6EDA07AF-CC7D-4643-B06B-304DCE4F529A Q37305913-7241FB26-DADB-43B0-85F7-6E687C1E21B9 Q37323740-CAB8C94A-B785-4793-8887-3DAED66EDA73 Q38008372-896D9CEE-5561-4BA6-82AC-ABC0975C51DD Q38058202-F506B7D3-34BB-4098-8641-C60F71D8161D Q38156022-69146F58-B3C2-4E0C-96AB-5DA8C72CB427 Q38171484-55778616-A2A1-4A11-B2FE-52EC810097AD Q38554083-773586DA-E0A9-4488-8830-7DF703B22638 Q39094595-8F62CCEC-A2CC-43AA-93C8-FCE549FC9B9C Q39389823-E58696ED-16A2-4691-AFBB-F3B4E9E180DD Q39421531-5BCC217B-F354-439C-9406-92025FF4DAA9 Q40183775-70F58D8B-898F-42AD-B37B-42C4B34609E9 Q42220379-CAF99CE0-234B-4A67-BDA8-08B7930BDE4C Q44587763-39E7F38E-C302-4BFB-BB98-6003343C3396 Q45406318-3AB93430-472A-462B-BE35-E734DD0FB0E0

P2860

Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease

http://www.wikidata.org/entity/Q37128372

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 07 January 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease

@en

Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease.

@nl

type

label

Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease

@en

Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease.

@nl

prefLabel

Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease

@en

Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease.

@nl

P1433

Q37128372-485FFF96-F182-40F5-B63A-AE4CEACB85C2

P1476

Q37128372-AAA28D7B-34C2-4BD6-B0D7-3BF4B51B2102

P2093

Q37128372-621EF864-5A47-4FFD-8200-E22B3E5807D2

Q37128372-93134EDA-E28B-4C52-BA42-F453808AACAE

Q37128372-94CDCD2D-986C-4265-A229-087ED5C792D5

Q37128372-A9C31F87-8F48-4F63-ADEF-DEB180A4E2E3

P2860

Q37128372-0AC5FFAD-05CE-4D62-AE56-C0F5AE6B858F

Q37128372-0C7CED7A-429D-4037-8BA2-A94037A632A5

Q37128372-0F6AB989-8F6A-407F-9A01-9CF6A214C0BB

Q37128372-0FCDA20D-840B-438E-A696-179403B6C27F

Q37128372-104BCED7-3137-452E-9A62-2DE6BA94BC26

Q37128372-14635DA2-32BA-48C9-A835-406F22A2FAD1

Q37128372-15CB472F-20FC-4208-A671-DC2245BFC95D

Q37128372-19EFA756-6D7C-438D-8603-7D7DF9957C09

Q37128372-1AFC7156-8F9D-4353-99DA-0AF0F3B8EFA9

Q37128372-1D46A5D1-D040-4B5B-A0CD-D48FCBFC7DAE

P304

Q37128372-91D73DBD-40A3-40E1-850C-710416D03326

P31

Q37128372-E378BB0E-226A-4806-8C95-C83EAEDF714C

P356

Q37128372-EE0AA80B-1137-4176-9758-3BDC2BDBEBF0

P433

Q37128372-FAED401D-D90A-4593-BE89-F75514A82F78

P478

Q37128372-04C033BF-F880-44B7-8370-AF3855EE13B8

P577

Q37128372-E80623F1-8938-4DB8-B343-B4C9D2C56779

P5875

Q37128372-428F066A-C6FD-4509-A056-125C9EA216B3

P698

Q37128372-28BAD73E-6D96-4123-BAFE-21699C2236EE

P932

Q37128372-0AF16B6C-4BE9-4FE9-8A4D-D0791BECBDF4

P356

P1433

Human Molecular Genetics

P1476

Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease

@en

P2093

Albee Messing

http://www.w3.org/2001/XMLSchema#string

Eric F Wawrousek

http://www.w3.org/2001/XMLSchema#string

Tracy L Hagemann

http://www.w3.org/2001/XMLSchema#string

Wilbert C Boelens

http://www.w3.org/2001/XMLSchema#string

P2860

Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis

MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase

Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner

The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10

Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease

Nuclear speckle localisation of the small heat shock protein alpha B-crystallin and its inhibition by the R120G cardiomyopathy-linked mutation

Protein aggregation and neurodegenerative disease

AlphaB-crystallin in lens development and muscle integrity: a gene knockout approach

Alpha-crystallin can function as a molecular chaperone

Transgene overexpression of alphaB crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion.

P304

1190-1199

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1093/HMG/DDP013

http://www.w3.org/2001/XMLSchema#string

P433

7

http://www.w3.org/2001/XMLSchema#string

P478

18

http://www.w3.org/2001/XMLSchema#string

P577

2009-01-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23763994

http://www.w3.org/2001/XMLSchema#string

P698

19129171

http://www.w3.org/2001/XMLSchema#string

P932

2655774

http://www.w3.org/2001/XMLSchema#string