Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).
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The importance of Ca(2+)-dependent mechanisms for the initiation of the heartbeatA coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.A paradigm shift for the heart's pacemaker.Synchronization of sinoatrial node pacemaker cell clocks and its autonomic modulation impart complexity to heart beating intervals.Computer algorithms for automated detection and analysis of local Ca2+ releases in spontaneously beating cardiac pacemaker cellsA novel quantitative explanation for the autonomic modulation of cardiac pacemaker cell automaticity via a dynamic system of sarcolemmal and intracellular proteins.Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome.Novel oscillatory mechanisms in the cholinergic control of Guinea pig sino-atrial node discharge.Synchronization of stochastic Ca²(+) release units creates a rhythmic Ca²(+) clock in cardiac pacemaker cellsStructural correlation method for model reduction and practical estimation of patient specific parameters illustrated on heart rate regulation.Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells.Catecholamine-independent heart rate increases require Ca2+/calmodulin-dependent protein kinase II.Ca2+-regulated-cAMP/PKA signaling in cardiac pacemaker cells links ATP supply to demand.The "funny" current (I(f)) inhibition by ivabradine at membrane potentials encompassing spontaneous depolarization in pacemaker cells.Impaired signaling intrinsic to sinoatrial node pacemaker cells affects heart rate variability during cardiac disease.Modern perspectives on numerical modeling of cardiac pacemaker cellNumerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac pacemaking.STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.RGS2 overexpression or G(i) inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cellsThe end effector of circadian heart rate variation: the sinoatrial node pacemaker cell.The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulationThe Autonomic Nervous System Regulates the Heart Rate through cAMP-PKA Dependent and Independent Coupled-Clock Pacemaker Cell MechanismsPhospholamban and cardiac function: a comparative perspective in vertebrates.Pharmacological Conversion of a Cardiac Inward Rectifier into an Outward Rectifier Potassium Channel.Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cellsPositive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials.
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P2860
Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 19 June 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Cholinergic receptor signaling ...... ed effects on PKA-dependent Ca
@nl
Cholinergic receptor signaling ...... nt Ca(2+) cycling and I(KACh).
@en
type
label
Cholinergic receptor signaling ...... ed effects on PKA-dependent Ca
@nl
Cholinergic receptor signaling ...... nt Ca(2+) cycling and I(KACh).
@en
prefLabel
Cholinergic receptor signaling ...... ed effects on PKA-dependent Ca
@nl
Cholinergic receptor signaling ...... nt Ca(2+) cycling and I(KACh).
@en
P2093
P2860
P50
P1476
Cholinergic receptor signaling ...... ent Ca(2+) cycling and I(KACh)
@en
P2093
Antoine Younes
H Bradley Nuss
Harold A Spurgeon
Ihor Zahanich
Tatiana M Vinogradova
P2860
P304
P356
10.1152/AJPHEART.01340.2008
P577
2009-06-19T00:00:00Z