Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. - Wikidata - wikimedia - TriplyDB

Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities.

Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities.

http://www.wikidata.org/entity/Q37394402

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Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart Gene-dosage effects in Down syndrome and trisomic mouse models The sequence of human chromosome 21 and implications for research into Down syndrome Down syndrome: searching for the genetic culprits On the promise of pharmacotherapies targeted at cognitive and neurodegenerative components of Down syndrome Prospects for Improving Brain Function in Individuals with Down Syndrome Dissecting Alzheimer disease in Down syndrome using mouse models Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues Chromosome 21 and down syndrome: from genomics to pathophysiology Animal models of intellectual disability: towards a translational approach Dosage of the Abcg1-U2af1 region modifies locomotor and cognitive deficits observed in the Tc1 mouse model of Down syndrome The use of mouse models to understand and improve cognitive deficits in Down syndrome.Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1).Alzheimer disease models and human neuropathology: similarities and differences PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-δ activation in mouse models of Down syndrome.The mouse brain transcriptome by SAGE: differences in gene expression between P30 brains of the partial trisomy 16 mouse model of Down syndrome (Ts65Dn) and normals Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model.Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome A chromosome 21 critical region does not cause specific Down syndrome phenotypes.Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome.Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome Meiotic behavior of aneuploid chromatin in mouse models of Down syndrome.Gene expression profiling in a mouse model identifies fetal liver- and placenta-derived potential biomarkers for Down Syndrome screening.Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes Segmental trisomy of chromosome 17: a mouse model of human aneuploidy syndromes An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks Brain phenotype of transgenic mice overexpressing cystathionine β-synthase.Genotype-phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21 The complex SNP and CNV genetic architecture of the increased risk of congenital heart defects in Down syndrome.Controlled somatic and germline copy number variation in the mouse model Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.Understanding mental retardation in Down's syndrome using trisomy 16 mouse models.Human neural stem cells: a new tool for studying cortical development in Down's syndrome.Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome.Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia.Mouse models for Down syndrome-associated developmental cognitive disabilities

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Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities.

http://www.wikidata.org/entity/Q37394402

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article científic

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bilimsel makale

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scientific article published on May 1998

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Ts1Cje, a partial trisomy 16 m ...... and behavioral abnormalities.

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Ts1Cje, a partial trisomy 16 m ...... and behavioral abnormalities.

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type

label

Ts1Cje, a partial trisomy 16 m ...... and behavioral abnormalities.

@en

Ts1Cje, a partial trisomy 16 m ...... and behavioral abnormalities.

@nl

prefLabel

Ts1Cje, a partial trisomy 16 m ...... and behavioral abnormalities.

@en

Ts1Cje, a partial trisomy 16 m ...... and behavioral abnormalities.

@nl

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PNAS.95.11.6256

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Proceedings of the National Academy of Sciences of the United States of America

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Ts1Cje, a partial trisomy 16 m ...... and behavioral abnormalities.

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P2093

C J Epstein

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D J Smith

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E J Carlson

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E M Rubin

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H Sago

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J Kilbridge

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T T Huang

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W C Mobley

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P2860

Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region"

A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission

Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

Single-minded and Down syndrome?

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

Place navigation impaired in rats with hippocampal lesions

Prenatal lethality in a transgenic mouse line is the result of a chromosomal translocation

Down syndrome phenotypes: the consequences of chromosomal imbalance.

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome.

Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase beta-subunit gene of the rd mouse.

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6256-6261

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10.1073/PNAS.95.11.6256

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