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Complexity and diversity of F8 genetic variations in the 1000 genomesCompound heterozygous hemophilia A in a female patient and the identification of a novel missense mutation, p.Met1093IleA new recombinant factor VIII: from genetics to clinical use.Expression and characterization of a codon-optimized blood coagulation factor VIII.Endothelial cell processing and alternatively spliced transcripts of factor VIII: potential implications for coagulation cascades and pulmonary hypertension.Mutations in intron 1 and intron 22 inversion negative haemophilia A patients from Western India.Suppression of inhibitor formation against FVIII in a murine model of hemophilia A by oral delivery of antigens bioencapsulated in plant cellsQuantitative correlation between transcriptional levels of ER chaperone, peroximal protein and FVIII productivity in human Hek-293 cell lineMost factor VIII B domain missense mutations are unlikely to be causative mutations for severe hemophilia A: implications for genotyping.Delivery of full-length factor VIII using a piggyBac transposon vector to correct a mouse model of hemophilia A.Intraosseous delivery of lentiviral vectors targeting factor VIII expression in platelets corrects murine hemophilia A.Human coagulation factor VIII domain-specific recombinant polypeptide expressionThe CDC Hemophilia A Mutation Project (CHAMP) mutation list: a new online resource.The first recombinant human coagulation factor VIII of human origin: human cell line and manufacturing characteristics.Transgene-host cell interactions mediate significant influences on the production, stability, and function of recombinant canine FVIIICircumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models.Immunomodulation for inhibitors in hemophilia A: the important role of Treg cellsClinical advances in hemophilia management.Turoctocog alfa (NovoEight®)--from design to clinical proof of concept.Obstacles and future of gene therapy for hemophilia.Potential for cellular stress response to hepatic factor VIII expression from AAV vectorIn silico analyses of missense mutations in coagulation factor VIII: identification of severity determinants of haemophilia A.Factor VIII and von Willebrand factor are ligands for the carbohydrate-receptor Siglec-5.Advances in Overcoming Immune Responses following Hemophilia Gene Therapy.Product-dependent anti-factor VIII antibodies.Retrospective analysis of differences in annual factor VIII utilization among haemophilia A patients.Expression studies of mutant factor VIII alleles with premature termination codons with regard to inhibitor formation.Structural analysis of the recombinant therapeutic product rFVIII and its PEGylated variants using 2-D DIGE.Can B-domain deletion alter the immunogenicity of recombinant factor VIII? A meta-analysis of prospective clinical studies.Characterization of five associations of F8 missense mutations containing FVIII B domain mutations.Laboratory testing for factor VIII and IX inhibitors in haemophilia: A review.Deep sequencing reveals different compositions of mRNA transcribed from the F8 gene in a panel of FVIII-producing CHO cell lines.Ca(2+) concentration-dependent conformational change of FVIII B-domain observed by atomic force microscopy.Mutational Profiles of and in a Cohort of Haemophilia A and Haemophilia B Patients in the Multi-ethnic Malaysian Population
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 07 April 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Functional roles of the factor VIII B domain.
@en
Functional roles of the factor VIII B domain.
@nl
type
label
Functional roles of the factor VIII B domain.
@en
Functional roles of the factor VIII B domain.
@nl
prefLabel
Functional roles of the factor VIII B domain.
@en
Functional roles of the factor VIII B domain.
@nl
P1433
P1476
Functional roles of the factor VIII B domain.
@en
P2093
P2860
P304
P356
10.1111/J.1365-2516.2009.02026.X
P577
2009-04-07T00:00:00Z