Cancer cell senescence: a new frontier in drug development.
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Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic StrategiesGenetics and epigenetics of aging and longevityTherapeutic targeting of replicative immortalityCell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.Escape of U251 glioma cells from temozolomide-induced senescence was modulated by CDK1/survivin signalingNovel ferrocenyl derivatives exert anti-cancer effect in human lung cancer cells in vitro via inducing G1-phase arrest and senescence.Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks.Increased SHP-1 expression results in radioresistance, inhibition of cellular senescence, and cell cycle redistribution in nasopharyngeal carcinoma cellsStructure-Function Analysis of the Mcl-1 Protein Identifies a Novel Senescence-regulating Domain.Repopulation of ovarian cancer cells after chemotherapySpecific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues.Inhibition of Autophagy Enhances Curcumin United light irradiation-induced Oxidative Stress and Tumor Growth Suppression in Human Melanoma CellsThe in situ local immune response, tumour senescence and proliferation in colorectal cancer.The unfolded protein response and cellular senescence. A review in the theme: cellular mechanisms of endoplasmic reticulum stress signaling in health and disease.Sudan Black B, The Specific Histochemical Stain for Lipofuscin: A Novel Method to Detect Senescent Cells.Genetics of melanoma progression: the rise and fall of cell senescence.A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgroundsTeng-Long-Bu-Zhong-Tang induces p21-dependent cell senescence in colorectal carcinoma LS174T cells via histone acetylation.Induction of DNA damage and p21-dependent senescence by Riccardin D is a novel mechanism contributing to its growth suppression in prostate cancer cells in vitro and in vivo.Depletion of HPV16 early genes induces autophagy and senescence in a cervical carcinogenesis model, regardless of viral physical state.Plasma N-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome.Down-regulation of wild-type p53-induced phosphatase 1 (Wip1) plays a critical role in regulating several p53-dependent functions in premature senescent tumor cells.Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics.Trabectedin modulates the senescence-associated secretory phenotype and promotes cell death in senescent tumor cells by targeting NF-κB.Distinct phenotypes and 'bystander' effects of senescent tumour cells induced by docetaxel or immunomodulatory cytokines
P2860
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P2860
Cancer cell senescence: a new frontier in drug development.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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Cancer cell senescence: a new frontier in drug development.
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Cancer cell senescence: a new frontier in drug development.
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type
label
Cancer cell senescence: a new frontier in drug development.
@en
Cancer cell senescence: a new frontier in drug development.
@nl
prefLabel
Cancer cell senescence: a new frontier in drug development.
@en
Cancer cell senescence: a new frontier in drug development.
@nl
P2093
P50
P1433
P1476
Cancer cell senescence: a new frontier in drug development
@en
P2093
Christopher J Torrance
Jon Roffey
T R Jeffry Evans
P304
P356
10.1016/J.DRUDIS.2012.01.019
P577
2012-01-31T00:00:00Z